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To analyse factors affecting decline in level of activities of daily living in patients with Alzheimer’s disease
XIAOTianyi, WANGHongquan, LIYanfeng
Chinese Journal of Alzheimer's Disease and Related Disorders ›› 2020, Vol. 3 ›› Issue (1) : 37-41.
PDF(473 KB)
Abbreviation (ISO4): Chinese Journal of Alzheimer's Disease and Related Disorders
Editor in chief: Jun WANG
PDF(473 KB)
To analyse factors affecting decline in level of activities of daily living in patients with Alzheimer’s disease
Objective: To analyze the factors influencing the decline of Ability of daily life in patients with mild to moderate Alzheimer’s disease. Methods: Sixty-four patients with mild to moderate Alzheimer’s disease were followed up for 16 weeks. MMSE, MoCA, ADCS-ADL and ADAS-cog were assessed at the beginning and after 16 weeks. Results: In the group without anti dementia drugs, MMSE score, MoCA score, ADCS-ADL score and ADAS-cog score were 20.50±3.53, 18.67±7.01, 17.50±11.73 and 45.17±4.28, respectively. After 16 weeks of observation, they were 18.25±6.23, 17.92±6.96, 18.67±12.23 and 43.67±7.72, respectively, all with deterioration trend, but there was no statistical significance before and after the observation; in the group treated with single anti dementia drug, the MMSE score, MoCA score, ADCS-ADL score and ADAS-cog score were 19.50±4.50, 17.30±5.47, 16.13±9.24 and 46.50±5.59, respectively, and they were 22.73±4.88, 17.83±6.34, 14.50±8.20 and 48.58±5.63 after 16 weeks of observation. There were significant differences in MMSE score, ADAS-cog score and ADCS-ADL score; The MMSE score, MoCA score, ADCS-ADL score and ADAS-cog score were 18.75±2.63, 18.58±5.02, 19.08±18.00 and 42.58±6.59 respectively in the combination group, and they were 24.83±6.22, 19.67±4.10, 16.42±15.54 and 48.00±5.83 respectively after 16 weeks of observation, the score was improved and the difference was statistically significant. Multiple linear regression analysis showed that education level, basic ADCS-ADL score, anti dementia treatment plan and care had influence on ADCS-ADL score (P<0.05). Conclusion: Early combination of anti dementia drugs and intensive care can improve the ability of daily life of AD patients, and education also plays a positive role.
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