Objective: To investigate the prevalence of cognitive function and risk factors in non disability people aged≥65 years in a welfare center in Shenzhen To provide a basis for effective prevention and treatment of cognitive impairment in this population. Methods: A cross-sectional survey was used to register the demographic data and related medical history of the participants. The height, weight, waist circumference and blood pressure were measured. The cognitive function was evaluated by the Mini Mental State Examination(MMSE). MMSE grades under normal value were defined as cognitive impairment (demarcation values: illiteracy ≤17 points, Primary School ≤20 points, secondary school and above group ≤ 24 points).Results: Among the 505 elderly people in the welfare center, 266 (about 52.7%) were with complete disability and mental retardation and unable to complete the cognitive function assessment, and 239 (47.3%) were able to complete the cognitive function assessment, in these non disability group there are 89 males (37.2%) and 150 females (62.8%), aged 65 to 100 years, with an average age of (83.24±6.11) years. The prevalence of cognitive impairment in the non disability people over 65 years is 40.2%. The prevalence of cognitive impairment in different age groups is statistically significant (P< 0.05), and the prevalence increases with age, it was 19.0% in the group of 74 to 74 years old, 29.8% in the group of 75 to 84 years old, and 55.8% in the group of 85 years old and above. The prevalence of cognitive impairment in different culture groups is statistically significant (P< 0.05), Logistic regression analysis showed that age was an independent risk factor for cognitive impairmentin this population (OR=1.079, 95%CI:1.028~1.132, P=0.002). Conclusion: The prevalence of cognitive impairment is highly in non disability people aged≥65 years in a welfare center in Shenzhen, and the prevalence gradually increases with age; age is an independent risk factor for cognitive impairment in this population. Education above junior middle school is a possible protective factor of cognitive dysfunction.