Research Progress of Natural Drugs Modulating Oxidative-Stress Response in Transgenic Mice of Alzheimer's Disease

GUO Ling; GUAN Xue; LI Qingyan; HU Jianying; ZHANG Hongjiang

doi:10.3969/j.issn.2096-5516.2021.01.001

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Chinese Journal of Alzheimer's Disease and Related Disorders ›› 2021, Vol. 4 ›› Issue (1) : 7-12. DOI: 10.3969/j.issn.2096-5516.2021.01.001

Research Progress of Natural Drugs Modulating Oxidative-Stress Response in Transgenic Mice of Alzheimer's Disease

GUO Ling ¹^,² ,
GUAN Xue ³ ,
LI Qingyan ⁴ ,
HU Jianying ⁴ ,
ZHANG Hongjiang ¹^,²

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Abstract

Alzheimer's disease (AD) is a common neurodegenerative disease with a variety of pathological changes. Oxidative stress plays an important role in the pathogenesis and development of AD. Based on the multifactorial characteristics in the onset mechanisms of AD, it requires that multi-type or multi-effect agents are with neuroprotective actions to AD be studied and dig out. Natural drugs may be better than sythetics because of their multi-pathway, multi-target and multi-effect characteristics. Transgenic animals models of AD have a variety of pathophysiological characteristics of AD. To target the prevention or treatment of AD, they are good for researchers to investigate and evaluate the effecacy of the natural drugs on the oxidative-stress responses in AD. This paper is going to review the previous studies on the effects of the oxidative-stress responses of the natural drugs on transgenic mice of AD. It can provide the theoretical basis and practical evidence to further studies in the future.

Key words

Alzheimer's disease / Transgenic mice / Natural medicine / Oxidative stress

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GUO Ling , GUAN Xue , LI Qingyan , et al . Research Progress of Natural Drugs Modulating Oxidative-Stress Response in Transgenic Mice of Alzheimer's Disease[J]. Chinese Journal of Alzheimer's Disease and Related Disorders. 2021, 4(1): 7-12 https://doi.org/10.3969/j.issn.2096-5516.2021.01.001

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