A case report of anti-LGI1 antibody encephalitis with rapidly progressing cognitive dysfunction and intractable hyponatremia

GUO Qiwen; QIU Guozhen; WANG Yin; XU Chunyan; CHEN Chunchun; LIN Yanwei; MENG Xueya; ZHU Feiqi

doi:10.3969/j.issn.2096-5516.2021.01.010

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Chinese Journal of Alzheimer's Disease and Related Disorders ›› 2021, Vol. 4 ›› Issue (1) : 56-59. DOI: 10.3969/j.issn.2096-5516.2021.01.010

Original article

A case report of anti-LGI1 antibody encephalitis with rapidly progressing cognitive dysfunction and intractable hyponatremia

GUO Qiwen ¹^,² ,
QIU Guozhen ¹^,² ,
WANG Yin ¹ ,
XU Chunyan ¹^,² ,
CHEN Chunchun ¹^,² ,
LIN Yanwei ¹^,² ,
MENG Xueya ¹^,² ,
ZHU Feiqi

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Abstract

This article reported a case of anti-leucine-rich glioma inactivation 1 protein (LGI1) antibody encephalitis. The patient was a middle-aged male, his clinical manifestations mainly were rapidly progressing cognitive dysfunction and intractable hyponatremia., brain MRIshowed hyperintensity in bilateral hippocampal, anti-LGI1 antibody of serum and cerebrospinal fluidwere both positive, then the diagnosis was anti-LGI1 antibody encephalitis. His cognitive dysfunction was significantly relieved after administration of glucocorticoid immunotherapy. This article analyzed the clinical characteristics of anti-LGI1 antibody encephalitis, and reviews related literature to alert middle-aged patients with sudden cognitive impairment. It was necessary to detect autoimmune encephalitis antibody markers in blood and cerebrospinal fluid, and actively immunize earlytreatment to control disease progression and improve prognosis.

Key words

Anti-leucine-rich glioma inactivation 1 protein (LGI1) / Encephalitis / Cognitive Dysfunction / Hyponatremia / Immunotherapy

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GUO Qiwen , QIU Guozhen , WANG Yin , et al . A case report of anti-LGI1 antibody encephalitis with rapidly progressing cognitive dysfunction and intractable hyponatremia[J]. Chinese Journal of Alzheimer's Disease and Related Disorders. 2021, 4(1): 56-59 https://doi.org/10.3969/j.issn.2096-5516.2021.01.010

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