CQ-MCI: a potential efficient cognitive screeningscale for mild cognitive impairment

Zixuan LIAO; Jiayu LI; Yidan LIU; Shuchun HUANG; Liumi JIANG; Xiaofeng LI

doi:10.3969/j.issn.2096-5516.2025.01.005

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Chinese Journal of Alzheimer's Disease and Related Disorders ›› 2025, Vol. 8 ›› Issue (1) : 29-35. DOI: 10.3969/j.issn.2096-5516.2025.01.005

CQ-MCI: a potential efficient cognitive screeningscale for mild cognitive impairment

Zixuan LIAO ¹ ,
Jiayu LI ¹ ,
Yidan LIU ² ,
Shuchun HUANG ³ ,
Liumi JIANG ³^,^* ,
Xiaofeng LI ¹^,^*

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Abstract

Objective:

Mild cognitive impairment (MCI) represents a crucial stage in the early diagnosis and intervention of dementia. MCI due to AD is the main type of MCI. Using a single cognitive screening scale for MCI has some shortcomings such as limited sensitivity and specificity. Meanwhile, using a comprehensive neuropsychological battery for MCI screening is time consuming and laborintensive. Therefore, this study aims to explore an efficient cognitive screening scale for Chinese population of MCI due to AD, based on previously used cognitive assessment tools.

Methods:

A total of 27 cognitive screening tests and the Clinical Dementia Rating (CDR) scale were administered to 242 participants: 121 in the control group (CDR=0) and 121 in the MCI group (CDR=0.5). Spearman correlation analysis was used to assess the relationship between Z scores of each test and CDR scores. Tests showing significant correlations were used to construct a new screening scale for MCI. Then conduct a preliminary analysis of the sensitivity and specificity of the new scale, and establish the scoring criteria for the new scale.

Results:

The results of the correlation analysis showed that among the neuropsychological tests in various cognitive domains, Visual Cognitive Assessment Test(VCAT)-Language (r=-0.447, P<0.001), VCAT-Memory (r=-0.717, P<0.001), Trail Making Test(TMT)-B (r=0.426, P<0.001), Mini-Mental State Examination(MMSE)-Orientation (r=-0.271, P=0.025), MMSE-Attention (r=-0.313, P=0.009), and Clock Drawing Test(CDT) (r=-0.407, P<0.001) had the strongest correlations with CDR scores. These six cognitive tests were used to construct a new scale. And pass/fail criteria was derived that determined "possible"(one test failed), "probable" (two tests failed), and "definite" MCI (three tests failed).

Conclusion:

VCAT-Language; VCAT-Memory, TMT-B, MMSE-Orientation, MMSE-Attention, and CDT tests can be integrated to form a new screening scale for MCI suitable for the Chinese population of MCI due to AD. Further clinical validation is needed in the future to assess the sensitivity and feasibility of CQ-MCI.

Key words

Mild cognitive impairment / Neuropsychological test / Screening scale

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Zixuan LIAO , Jiayu LI , Yidan LIU , et al . CQ-MCI: a potential efficient cognitive screeningscale for mild cognitive impairment[J]. Chinese Journal of Alzheimer's Disease and Related Disorders. 2025, 8(1): 29-35 https://doi.org/10.3969/j.issn.2096-5516.2025.01.005

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