A case report of sCJD manifested as muscle dystonia

JIAN Wenjia; SHEN Shaozhen; YANG He; ZHEN Fei; DOU Jinjuan

doi:10.3969/j.issn.2096-5516.2025.04.005

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Chinese Journal of Alzheimer's Disease and Related Disorders ›› 2025, Vol. 8 ›› Issue (4) : 248-252. DOI: 10.3969/j.issn.2096-5516.2025.04.005

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A case report of sCJD manifested as muscle dystonia

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Abstract

Objective: To investigate the characteristic of sporadic Creutzfeldt-Jakob disease(sCJD), improve the knowledge of sCJD for clinicians. Methods: We collected the clinical data, brain neuroimages and laboratory test results of a case of sCJD and reviewed relative articles. Results: The patient showed limb rigidity, involuntary movements, myoclonic jerks, speech disorders, rapidly progressive cognitive impairment, and later autonomic dysfunction, and passed away 8 months after the onset. Conclusion: The early symptoms of sCJD are atypical, varied and heterogeneous, with a high fatality rate. The diagnosis of CJD requires attention to distinguishing it from various diseases, and dynamic examination of cerebrospinal fluid, brain MRI, electroencephalogram, and even biopsy to avoid misdiagnosis and missed diagnosis.

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Creutzfeldt-Jakob disease / Diagnosis / Differential diagnosis

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JIAN Wenjia , SHEN Shaozhen , YANG He , et al . A case report of sCJD manifested as muscle dystonia[J]. Chinese Journal of Alzheimer's Disease and Related Disorders. 2025, 8(4): 248-252 https://doi.org/10.3969/j.issn.2096-5516.2025.04.005

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