Research progress on mechanisms, risk factors and treatment of comorbidity of Alzheimer's disease and osteoporosis

JING Chaonan, WANG Jiangbo, ZHANG Guanqun

Chinese Journal of Alzheimer's Disease and Related Disorders ›› 2025, Vol. 8 ›› Issue (4) : 278-284.

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Chinese Journal of Alzheimer's Disease and Related Disorders

Abbreviation (ISO4): Chinese Journal of Alzheimer's Disease and Related Disorders      Editor in chief: Jun WANG

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Chinese Journal of Alzheimer's Disease and Related Disorders ›› 2025, Vol. 8 ›› Issue (4) : 278-284. DOI: 10.3969/j.issn.2096-5516.2025.04.010
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Research progress on mechanisms, risk factors and treatment of comorbidity of Alzheimer's disease and osteoporosis

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Abstract

Alzheimer's disease (AD) and osteoporosis (OP) are both age-related degenerative diseases,which mainly occur in the elderly population over the age of 60, and are becoming an increasingly common combination in the aging population. It has been proved that a variety of factors can stimulate and accelerate the occurrence of AD and OP in clinical practice. This review mainly studies the common pathogenesis of AD and OP, and discusses the pathogenesis factors such as vitamin D and vitamin K levels, signaling pathways, apolipoprotein and neuroinflammation in AD mouse models. In addition,potential treatments for these two diseases are described.

Key words

Alzheimer's disease / Osteoporosis / Signal path / Vitamin / Neuroinflammation

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JING Chaonan , WANG Jiangbo , ZHANG Guanqun. Research progress on mechanisms, risk factors and treatment of comorbidity of Alzheimer's disease and osteoporosis[J]. Chinese Journal of Alzheimer's Disease and Related Disorders. 2025, 8(4): 278-284 https://doi.org/10.3969/j.issn.2096-5516.2025.04.010

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