Meta-analysis of the prevalence of frailty in Alzheimer's patients

Quanzi LONG; Xilin LIAO; Youmei SU; Chenlu ZHOU; Kuiyu FAN

doi:10.3969/j.issn.2096-5516.2025.05.008

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Chinese Journal of Alzheimer's Disease and Related Disorders ›› 2025, Vol. 8 ›› Issue (5) : 334-341. DOI: 10.3969/j.issn.2096-5516.2025.05.008

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Meta-analysis of the prevalence of frailty in Alzheimer's patients

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Abstract

Objective: To conduct a meta-analysis on the incidence of frailty in patients with Alzheimer's Disease (AD), in order to provide a scientific basis for the prevention of frailty in AD patients. Methods: By systematically searching CNKI, Wanfang, VIP Chinese databases, PubMed, Web of Science, Embase and Cochrane Library English databases, the epidemiological evidence of the incidence of frailness in AD patients was comprehensively obtained. The literature search period was set from the establishment of the database to March 10, 2025, and literature screening, data extraction and bias risk assessment were carried out by two researchers respectively. Statistical software Stata14.0 was used to conduct a meta-analysis of the included studies. Results: Thirteen studies were included, covering 2806 patients with Alzheimer's disease, and the analysis suggested an overall incidence of frailty of 34% (95%CI: 27%~41%). Study area, measurement tool, study time, sample size and other factors have an impact on the incidence of frailty in patients with Alzheimer's disease. Conclusion: The incidence of frailties in patients with Alzheimer's disease is high. Attention should be paid to frailties in patients with Alzheimer's disease, and early detection and intervention measures should be taken to reduce the occurrence of frailties in this population.

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Alzheimer's disease / Frailty / Prevalence / Meta-analysis

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Quanzi LONG , Xilin LIAO , Youmei SU , et al . Meta-analysis of the prevalence of frailty in Alzheimer's patients[J]. Chinese Journal of Alzheimer's Disease and Related Disorders. 2025, 8(5): 334-341 https://doi.org/10.3969/j.issn.2096-5516.2025.05.008

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