Analysis of risk factors for deep venous thrombosis in elderly patients with dementia complicated by post-stroke hemiplegia

Lingjie HUA

doi:10.3969/j.issn.2096-5516.2026.03.005

PDF(5253 KB)

Chinese Journal of Alzheimer's Disease and Related Disorders ›› 2026, Vol. 9 ›› Issue (3) : 173-176. DOI: 10.3969/j.issn.2096-5516.2026.03.005

ResearchArticles

Analysis of risk factors for deep venous thrombosis in elderly patients with dementia complicated by post-stroke hemiplegia

Lingjie HUA

Author information +

History +

Abstract

Objective: To explore the retrospective risk factors for deep venous thrombosis (DVT) in elderly patients with dementia complicated by post-stroke hemiplegia. Compare the stroke-related indicators, treatment and nursing factors, and laboratory parameters between the two groups, and perform multivariate analysis to identify the risk and protective factors for DVT. Compare the stroke-related indicators, treatment and nursing factors, and laboratory parameters between the two groups, and perform multivariate analysis to identify the risk and protective factors for DVT. Methods: A retrospective analysis was conducted on 100 elderly patients with dementia and post-stroke hemiplegia who visited our hospital from January 2024 to August 2025.They were divided into a thrombosis group (n=40) and a non-thrombosis group (n=60) based on whether they developed DVT. The general characteristics, stroke-related indicators, treatment and nursing factors, and laboratory indicators between the two groups were compared. Multivariate analysis was performed to identify risk and protective factors for DVT.. Stroke severity, severe paralysis, prolonged bed rest, diuretic use, elevated D-dimer, high FIB, and shortened PT/APTT were independent risk factors for DVT. Early rehabilitation and prophylactic anticoagulation were significant independent protective factors (P<0.05). Conclusions: The occurrence of DVT in elderly patients with dementia complicated by post-stroke hemiplegia is closely associated with multiple factors. Severe stroke, profound paralysis, prolonged bed rest, diuretic use, elevated D-dimer, high fibrinogen, and shortened PT/APTT are independent risk factors for DVT, while early rehabilitation and prophylactic anticoagulation represent significant independent protective factors.

Key words

Dementia / Stroke / Hemiplegia / Deep vein thrombosis

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

Lingjie HUA. Analysis of risk factors for deep venous thrombosis in elderly patients with dementia complicated by post-stroke hemiplegia[J]. Chinese Journal of Alzheimer's Disease and Related Disorders. 2026, 9(3): 173-176 https://doi.org/10.3969/j.issn.2096-5516.2026.03.005

References

List( Publishing order | Descend order by publishing year | Descend order by cited within ) Chart analysis

[1]	沈付兰, 邹婷. 针刺疗法联合运动康复治疗对急性脑卒中偏瘫患者肢体运动功能的影响[J]. 淮海医药, 2025, 43(1):57-60. Cited in this article [1]

[2]	熊焱臻, 张月娟, 钟峰, 等. 缺血性脑卒中偏瘫患者住院期间下肢深静脉血栓形成的危险因素分析[J]. 血管与腔内血管外科杂志, 2025, 11(5):618-622. Cited in this article [1]

[3]	田金洲, 解恒革, 王鲁宁, 等. 中国老年保健协会阿尔茨海默病分会(ADC)指南小组.中国阿尔茨海默病痴呆诊疗指南(2020年版)[J]. 中华老年医学杂志, 2021, 40(3):269-283. Cited in this article [1]

[4]

Mistry

E A

, Yeatts

S D

, Khatri

, et al. National institutes of health stroke scale as an outcome in stroke research: Value of ANCOVA over analyzing change from baseline[J]. Stroke, 2022, 53(4):e150-e155.

https://doi.org/10.1161/STROKEAHA.121.034859

https://www.ncbi.nlm.nih.gov/pubmed/35012328

Cited in this article [1] Abstract

National Institutes of Health Stroke Scale (NIHSS), measured a few hours to days after stroke onset, is an attractive outcome measure for stroke research. NIHSS at the time of presentation (baseline NIHSS) strongly predicts the follow-up NIHSS. Because of the need to account for the baseline NIHSS in the analysis of follow-up NIHSS as an outcome measure, a common and intuitive approach is to define study outcome as the change in NIHSS from baseline to follow-up (ΔNIHSS). However, this approach has important limitations. Analyzing ΔNIHSS implies a very strong assumption about the relationship between baseline and follow-up NIHSS that is unlikely to be satisfied, drawing into question the validity of the resulting statistical analysis. This reduces the precision of the estimates of treatment effects and the power of clinical trials that use this approach to analysis. ANCOVA allows for the analysis of follow-up NIHSS as the dependent variable while adjusting for baseline NIHSS as a covariate in the model and addresses several challenges of using ΔNIHSS outcome using simple bivariate comparisons (eg, a test, Wilcoxon rank-sum, linear regression without adjustment for baseline) for stroke research. In this article, we use clinical trial simulations to illustrate that variability in NIHSS outcome is less when follow-up NIHSS is adjusted for baseline compared to ΔNIHSS and how a reduction in this variability improves the power. We outline additional, important clinical and statistical arguments to support the superiority of ANCOVA using the final measurement of the NIHSS adjusted for baseline over, and caution against using, the simple bivariate comparison of absolute NIHSS change (ie, delta).

[5]	符晓艳, 甘小娅, 王敏, 等. 肌力分级的功能训练视频宣教对脑梗死偏瘫患者康复效果的影响[J]. 重庆医学, 2023, 52(24):3770-3774. Cited in this article [1]

[6]	刘天鹰, 段欣, 张改, 等. 下肢静脉常规超声检查联合CT血管造影技术在缺血性脑卒中后下肢深静脉血栓形成评估中的研究[J]. 中国医学装备, 2025, 22(3):63-67. Cited in this article [1]

[7]	王建, 魏敬超, 董建民. 针刺联合低分子肝素钙预防缺血性脑卒中后下肢深静脉血栓形成的效果[J]. 中国民间疗法, 2025, 33(10):59-62. Cited in this article [1]

[8]	李叶子, 余平. 踝泵训练联合低分子肝素钙治疗脑卒中偏瘫合并下肢深静脉血栓有效性及安全性[J]. 中国实用神经疾病杂志, 2024, 27(5):616-621. Cited in this article [1]

[9]	席富强, 常昕, 董向力. 急性缺血性脑卒中伴发下肢深静脉血栓应用低分子肝素钙治疗的效果评估[J]. 中国实用医药, 2024, 19(11):100-103. Cited in this article [1]