Abbreviation (ISO4): Chinese Journal of Alzheimer's Disease and Related Disorders
Editor in chief: Jun WANG
Chinese Journal of Alzheimer's Disease and Related Disorders >
Potential neurotoxicity of silica nanoparticles: implications for neurodegenerative diseases
Received date: 2024-01-25
Revised date: 2025-03-01
Online published: 2024-04-26
Neurodegenerative diseases, or Neurodegenerative-related diseases (NRDs), is a kind of chronic diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and frontotemporal dementia (FTD). The common path- physiological characteristics of these diseases are including abnormal protein accumulation in the neurons, oxidative stress or mitochondrial dysfunction, which result in possible neuronal death. So far there have been none of cure in the therapitic methods to these diseases. However, there are some strategies of treatments can help to relieve symptoms or delay the progression of these diseases. Silica nanoparticles (SiNPs) is a new type of material, as a drug carrier in the medical field or a neuroprotective agent in neuroscience. However, recent studies have shown that it may have negative effects on neurodegenerative diseases. It is necessary that the biosafety of SiNPs on nervous system and its working mechanisms will be further studied. Therefore, to provide a theoretical or practical guidance to people, based on the recent literatures, a review summarizes some relevent preclinical studies on SiNPs applications and its effects on neuroinflammation, mitochondrial dysfunction, Aβ and p-Tau, will be reported here by us.
Kexin HE , Ling GUO . Potential neurotoxicity of silica nanoparticles: implications for neurodegenerative diseases[J]. Chinese Journal of Alzheimer's Disease and Related Disorders, 2024 , 7(2) : 151 -155 . DOI: 10.3969/j.issn.2096-5516.2024.02.012
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