Abbreviation (ISO4): Chinese Journal of Alzheimer's Disease and Related Disorders
Editor in chief: Jun WANG
Chinese Journal of Alzheimer's Disease and Related Disorders >
Functional connectivity of piriform is disrupted in AD and MCI: A preliminary analysis
Received date: 2020-01-02
Revised date: 2020-01-05
Online published: 2020-03-25
Objective: Olfactory deficits, present in Alzheime’s disease (AD) and mild cognitive impairment (MCI), coincide with the earliest presence of AD pathology. Therefore, we examined the olfactory network and hypothesized a decrease in connectivity of the olfactory network in AD and MCI patients. Methods: Twenty-seven control, 21 MCI, and 15 AD subjects completed olfactory functional MRI to investigate the functional connectivity (FC) of the piriform. Results: Bilateral piriform showed decreased connectivity to regions involved in olfaction in patient groups compared to controls (ANOVA, P<0.001). Conclusion: The olfactory network, which include regions also involved in emotion processing, is disconnected in AD and MCI patients with potential lateralization of dysfunction to the left side. This disconnection suggest the potential of the olfactory system as a diagnostic biomarker and may provide possible explanation for the high comorbidity of apathy and anhedonia in AD.
M. Vasavada Megha , ZHANG Han , McHugh Robert , WANG Jianli , PANG Ran , J. Eslinger Paul , Karunanayaka Prasanna , YANG Qingxian . Functional connectivity of piriform is disrupted in AD and MCI: A preliminary analysis[J]. Chinese Journal of Alzheimer's Disease and Related Disorders, 2020 , 3(1) : 17 -24 . DOI: 10.3969/j.issn.2096-5516.2020.01.006
表1 一般资料和行为学数据 |
指标 | CN (n = 27) | MCI (n = 21) | AD (n = 15) |
---|---|---|---|
男/女 | 12/15 | 10/11 | 5/10 |
年龄(岁) | 69.5 ± 10.4 | 73.2 ± 9.0 | 71.9 ± 11.9 |
受教育年限(年) | 16.0 ± 1.7 | 14.6 ± 2.9 | 14.3 ± 3.0 |
CDR | 0 | 0.5 | 0.5 or 1 |
UPSIT | 34.0±4.2 | 24.2 ± 8.6* | 15.5 ± 8.4*,† |
MMSE | 28.5 ± 1.5 | 26.5 ± 1.9 | 18.9 ± 5.4*,† |
CVLT-Ⅱ | 62.6 ± 13.1 | 47.3 ± 12.7* | 21.3 ± 14.1*,† |
DRS-2 | 13.3 ± 1.6 | 9.6 ± 3.2* | 3.9 ± 2.5*,† |
缩写:CN:认知正常对照组;MCI:轻度认知障碍;AD:阿尔茨海默病;CDR:临床痴呆评分值;UPSIT:宾夕法尼亚州立大学气味识别测试;MMSE:简易精神状态测试;CVLT-Ⅱ:简化加利福尼亚语言学习测验第二版;DRS-2:Mattis痴呆评分量表-2。 注:均值 ± 标准差 * P<0.05, 方差分析,与CN比较 †P<0.05, 方差分析,与MCI比较 |
图1 梨状皮层功能连接图各组激活脑区分布图(单样本t检验;CN:P<0.001, FEW,MCI和AD:P<0.05,FEW;阈值=6像素)。以蒙特利尔神经病学研究所空间标准化T1加权图像为背景,左侧梨状皮层(A)和右侧梨状皮层(B)与其他脑区连接减弱区,分布在海马,尾状核,苍白球,伏隔核,眶额皮层,前扣带,小脑和视觉皮层。 |
作者感谢Christopher W. Weitekamp and Jeffrey Vesek帮助搜集数据
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