Abbreviation (ISO4): Chinese Journal of Alzheimer's Disease and Related Disorders
Editor in chief: Jun WANG
Chinese Journal of Alzheimer's Disease and Related Disorders >
Research progress of peripheral blood biomarkers of Alzheimer’s disease
Received date: 2019-08-01
Revised date: 2019-08-09
Online published: 2019-12-25
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by progressivecognitive impairment. With the rapid aging of China, the disease burden is becoming heavier. In order to early prevent and treat the disease, researchers committed to find effective and easily detectable biomarkers for early recognition of AD. Among them, the peripheral blood biomarkers detection is a potential method for early screening and follow-up in the community population because of its convenient collection and little trauma. In this paper, the research progress of peripheral blood biomarkers of AD was reviewed.
Key words: Alzheimer’s disease; Peripheral blood biomarkers
QIAO Xinyi , YUE Ling , XIAO Shifu . Research progress of peripheral blood biomarkers of Alzheimer’s disease[J]. Chinese Journal of Alzheimer's Disease and Related Disorders, 2019 , 2(4) : 548 -555 . DOI: 10.3969/j.issn.2096-5516.2019.04.016
表1 外周血生物标志物 |
种类 | 标志物 | 检测标本 | 浓度变化 | 疾病阶段 | 参考文献 |
---|---|---|---|---|---|
Aβ | Aβ42 | 血浆 | 升高 | AD | [3-4] |
Aβ40 | 血浆 | 升高 | AD | [5] | |
Aβ38 | 血浆 | 降低 | AD | [11] | |
Aβ42/Aβ40 | 血浆 | 降低 | AD/MCI | [7⇓-9] | |
Tau蛋白 | T-Tau | 血浆 | 升高 | AD/MCI | [14-15,19] |
载脂蛋白 | ApoE | 血浆 | 升高 | AD | [27-28] |
降低 | [25-26] | ||||
ApoJ | 血浆 | 升高 | AD/MCI | [35⇓-37] | |
ApoA1 | 血浆 | 降低 | AD/MCI | [39-40] | |
ApoA2, ApoH | 血浆 | 降低 | AD/MCI | [39] | |
ApoC3 | 血浆 | 降低 | AD/MCI | [41] | |
ApoB, ApoB/ApoA1 | 血浆 | 升高 | AD/MCI | [39,42] | |
炎症相关 | CRP | 血浆 | 降低 | AD | [44] |
IL-6 | 血浆 | 降低 | AD | [47] | |
IL-4, IL-10, TNF-α | 血浆 | 降低 | AD | [48] | |
补体途径 | CFH | 血浆 | 升高 | AD/MCI | [49] |
CFI, TCC | 血浆 | 降低 | MCI | [51] | |
C3, C4, CFB | 血浆 | 升高 | AD | [50] | |
miRNA | miR-455-3p | 血清 | 升高 | AD | [55] |
miR-29c-3p, miR-19b-3p | 血清 | 降低 | AD | [56] | |
miR-501-3p | 血清 | 降低 | AD | [57] | |
miR-223 | 血清 | 降低 | AD | [58] | |
miR-502-3p, miR-483-5p | 血浆 | 升高 | AD/MCI | [59] | |
miR-411 | 血浆 | 升高 | AD | [60] | |
外泌体 | Aβ42, T-Tau, P-Tau | 血浆外泌体 | 升高 | AD | [64] |
NfL | NfL | 血浆 | 升高 | AD/MCI | [67,69] |
其他蛋白 | TTR | 血浆 | 降低 | AD/MCI | [72] |
GSN | 血浆 | 降低 | AD | [76-77] | |
DBP | 血清 | 升高 | AD/MCI | [78] | |
纤维蛋白原γ链 | 血浆 | 升高 | AD | [79] | |
激肽释放酶8 | 血浆 | 升高 | AD | [80] | |
DEP | 血浆 | 降低 | AD | [79] |
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