Abbreviation (ISO4): Chinese Journal of Alzheimer's Disease and Related Disorders
Editor in chief: Jun WANG
Chinese Journal of Alzheimer's Disease and Related Disorders >
Gender prevalence and influencing factors of amnesic mild cognitive impairment and Alzheimer’s disease: a cross-sectional study of the elderly population in Shanghai community
Received date: 2019-08-17
Revised date: 2019-08-24
Online published: 2019-12-25
Objective: To explore the gender prevalence of amnesic mild cognitive impairment (aMCI) and Alzheimer’s disease (AD) in the elderly population of Shanghai community and its related influencing factors. Methods: The elderly population in the community were divided into two groups according to gender. The two groups were investigated with standardized questionnaire. The Chinese version of mini-mental state examination (MMSE), the Chinese version of montreal cognitive assessment (MoCA), the Chinese version of NTB and the elderly depression scale were used to evaluate the cognitive function. The prevalence of aMCI and AD were compared between the two groups. The multiple Logistic regression was used for Regression analysis of the cognitive function of the relevant factors. Results: The prevalence of aMCI and ad in elderly men was 14.6% and 2.4% respectively; the prevalence of aMCI and ad in elderly women was 27.8% and 6.5% respectively, which was significantly higher than that in elderly men (P< 0.05); the comparison of general demographic data of aMCI, ad and normal population showed that the age and education of aMCI and AD in women were higher than that in normal elderly people. The Logistic regression equation showed that age (P< 0.001, OR=1.076) was the risk factor of aMCI, education (P< 0.001, OR=0.878) was the protective factor of aMCI, age (P< 0.001, OR=1.220) was the risk factor of AD, education (P< 0.05, OR=0.818) was the protective factor of AD. Conclusion: prevalence of aMCI and ad in elderly women is higher than that in men. Age is the risk factor of aMCI and AD, and education is the protective factor of aMCI and AD. The continuous learning of elderly women is helpful to prevent the development of aMCI into AD.
MA Li , LI Wei , YUE Ling , XIAO Shifu . Gender prevalence and influencing factors of amnesic mild cognitive impairment and Alzheimer’s disease: a cross-sectional study of the elderly population in Shanghai community[J]. Chinese Journal of Alzheimer's Disease and Related Disorders, 2019 , 2(4) : 531 -536 . DOI: 10.3969/j.issn.2096-5516.2019.04.013
表1 男女aMCI及AD患病率的比较 |
组别 | 男性(n=419) | 女性(n=586) | χ2 | P | 95% 置信区间 | |
---|---|---|---|---|---|---|
aMCI, n(%) | 61(14.6) | 163(27.8) | 24.790 | <0.001 | 0.000 | 0.006 |
AD, n(%) | 10(2.4) | 38(6.5) | 9.021 | 0.002 | 0.000 | 0.010 |
表2 老年女性aMCI、AD及正常老年人群的一般人口学资料比较 |
影响因素 | aMCI(n=163) | AD(n=38) | NC(n=313) | F/x2 | P |
---|---|---|---|---|---|
年龄/年 | 76.58±7.8 | 82.2±5.4 | 70.1±7.6 | 69.185 | <0.001 |
教育/年 | 4.1±4.4 | 3.12±3.9 | 8.0±4.2 | 51.007 | <0.001 |
吸烟,n(%) | 10(6.1) | 2(5.3) | 10(3.2) | 1.178 | 0.309 |
饮酒,n(%) | 5(3.1) | 1(2.6) | 13(4.2) | 0.242 | 0.785 |
饮茶,n(%) | 30(18.4) | 8(21.1) | 71(22.7) | 0.585 | 0.557 |
运动,n(%) | 89(54.6) | 18(47.4) | 196(62.6) | 2.572 | 0.077 |
业余爱好,n(%) | 57(35.0) | 151(48.2) | 7(18.4) | 8.740 | <0.001 |
高血压,n(%) | 79(48.5) | 18(47.4) | 141(45.0) | 0.260 | 0.771 |
糖尿病,n(%) | 27(16.6) | 8(21.0) | 45(14.4) | 0.481 | 0.619 |
表3 老年女性aMCI、AD多元因素分析 |
诊断 | 影响因素 | B | 标准误差 | Wald | df | P | OR | 95% | 置信区间 |
---|---|---|---|---|---|---|---|---|---|
aMCI | 年龄 | 0.073 | 0.016 | 19.784 | 1 | 0.000 | 1.076 | 1.042 | 1.111 |
教育 | -0.130 | 0.028 | 21.216 | 1 | 0.000 | 0.878 | 0.831 | 0.928 | |
AD | 年龄 | 0.199 | 0.033 | 36.215 | 1 | 0.000 | 1.220 | 1.144 | 1.302 |
教育 | -0.102 | 0.051 | 4.058 | 1 | 0.044 | 0.903 | 0.818 | 0.997 |
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