Abbreviation (ISO4): Chinese Journal of Alzheimer's Disease and Related Disorders
Editor in chief: Jun WANG
Chinese Journal of Alzheimer's Disease and Related Disorders >
Evaluation on acupuncture treatment in mild Alzheimer’s disease by 3D-ASL
Received date: 2019-07-18
Revised date: 2019-07-26
Online published: 2019-12-25
Objective: To investigate the changes of cerebral blood flow perfusion in patients with mild Alzheimer’s disease (AD) by three-dimensional arterial spin labeling (3D-ASL), and to evaluate the therapeutic effect of ad acupuncture at “siguan point”. Methods: Twenty mild AD patients (AD group) diagnosed by the neurological memory disorders clinic of Xuanwu Hospital, Capital Medical University from June 2016 to April 2018 and twenty normal volunteers matched with age, gender and education level of AD group were recruited as control group. 20 patients were randomly divided into two groups: “siguan" conventional acupuncture group (10 patients), and “siguan" sham acupuncture group (10 patients). All subjects underwent 3D-ASL scanning to get relative cerebral blood flow data at the time of enrollment, and neuropsychological scale examination was conducted. 3D-ASL scanning was performed again after intervention of acupuncture. The images were processed and analyzed using the software package SPM12. Results: In the “siguan" conventional acupuncture group, 2 cases were excluded because of the significant head movement artifacts. ①There was no statistical difference in age, gender and level of education between the mild AD group and NC group (P> 0.05). The scores of MMSE and MoCA in mild AD group was significantly lower than that of NC group; ② Compared with the NC group, decreased perfusion areas were observed in the bilateral precuneus and posterior cingulate cortex in the mild AD group (cluster number was 878, P< 0.05); (3) ③After 6 months of acupuncture intervention, 3D-ASL was reexamined. It was found that, the perfusion of left anterior cuneiform lobe and posterior cingulate cortex was increased, in addition, the perfusion of bilateral middle frontal cortex, superior frontal cortex, putamen nucleus, caudate nucleus, rectus muscles, left inferior frontal cortex, insula, right thalamus, superior temporal cortex central sulcus were also increased in the conventional acupuncture group. while that of the shallow acupuncture group was decreased in corresponding areas.(cluster number was 11 279, P< 0.05). Conclusion: 3D-ASL discovered that the perfusion of bilateral anterior cuneiform lobe and posterior cingulate cortex was decreased in mild AD and acupuncturing “siguan" point increased the cerebral perfusion (including the original hypoperfusion brain area) in mild AD patients.
MA Tian , LI Hui , FAN Xiang , NI Hong , QI Zhigang , LI Kuncheng . Evaluation on acupuncture treatment in mild Alzheimer’s disease by 3D-ASL[J]. Chinese Journal of Alzheimer's Disease and Related Disorders, 2019 , 2(4) : 481 -487 . DOI: 10.3969/j.issn.2096-5516.2019.04.003
表1 轻度AD组与正常对照组的基本临床资料比较( $\bar{x}±s$) |
组别 | 例数 | 性别 | 年龄/岁 | 受教育年限/年 | MMSE评分/分 | MoCA评分/分 | |
---|---|---|---|---|---|---|---|
男 | 女 | ||||||
轻度AD组 | 20 | 6 | 14 | 70.0±8.3 | 13.7±3.0 | 21.3±4.2 | 17.5±4.4 |
正常对照组 | 20 | 7 | 13 | 67.2±6.2 | 12.5±2.6 | 28.9±0.8 | 26.3±2.1 |
t值 | -1.243 | -1.267 | 7.600 | 8.051 | |||
P值 | 0.221 | 0.263 | 0.000 | 0.001 |
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