聚合物多孔表界面材料的构筑及给药应用*

陈彦臣, 钱泓霖, 郭一蓉, 汪璟, 计剑

化学进展 ›› 2024, Vol. 36 ›› Issue (5) : 679-695.

PDF(86508 KB)
PDF(86508 KB)
化学进展 ›› 2024, Vol. 36 ›› Issue (5) : 679-695. DOI: 10.7536/PC230919
综述

聚合物多孔表界面材料的构筑及给药应用*

作者信息 +

Polymeric Porous Surface Materials: Construction and Drug Delivery Applications

Author information +
文章历史 +

摘要

Medicine-device combined medical biomaterials provide a broad prospect for the development of traditional medical devices through the organic combination of drugs and devices. With the increasing clinical demand, the development of new surface and interface engineering technology and drug controlled release mechanism has become a hot research topic. In recent years, the porous surface and interface technology of polymer materials has realized the rapid combination of functional molecules and devices through capillary adsorption, which has the characteristics of flexible loading, controllable dosage and adjustable release, and provides new potential for promoting the precision and personalization of the combination of medical biomaterials and devices. In this review, we first summarize the preparation of porous surface and interface of polymer materials, including breathing diagram method, template method, surface non-solvent-induced phase separation method, stimulus-induced phase separation method and electrospinning method, and then elaborate the mechanism and release behavior of functional molecule delivery based on porous surface and interface of polymer materials.Then, the research progress of polymer porous surface and interface in the fields of targeted anticancer, cardiovascular implant materials, bone repair materials and so on is summarized.Finally, the challenges faced by the research of polymer porous surface and interface are summarized, and the development direction is prospected.

Abstract

combination products present significant opportunities for advancing traditional medical devices by versatile integration of therapeutic drugs and devices.as clinical needs evolve,there remains growing interest in developing new surface and interface engineering technologies for modulating drug delivery behavior.Recently,polymeric porous surface interface technology has emerged As a robust strategy for the flexible amalgamation of functional molecules with medical devices via capillary adsorption.in comparison to the conventional coating method,This technology shows distinctive features like flexible loading,facile dosage control,and tunable release,therefore providing a novel insight for personalized medicine.This review begins by outlining the methods for preparing porous surfaces of polymer materials,including the breath figure,template method,surface non-solvent-induced phase separation,stimulus-induced phase separation method,and electrospinning method.Then,the mechanism for the capillary-based loading process and hindered release behavior of functional species,which play a central role in the development of spongy surface-based Combination devices,is discussed.This review also provides an overview of the latest research on the porous surface interfaces of polymer materials in applications like targeted anti-cancer,cardiovascular implants,and bone repair,summarizes the present challenges in research on the porous surfaces of polymer materials,and highlights insights into potential future directions。

Contents

1 Introduction

2 Construction strategy of porous surface on polymer materials

2.1 Breath figure

2.2 Template method

2.3 Surface non solvent induced phase separation

2.4 Stimulus-induced phase separation

2.5 Electrospinning method

3 Functional molecule delivery based on porous polymer surface

3.1 The driving force of loading and release of functional molecules

3.2 Study on the release behavior of functional molecules

4 Application of polymer porous surface in drug delivery

4.1 Targeted anti-cancer

4.2 Cardiovascular diseases

4.3 Orthopedics diseases

5 Conclusion

关键词

药械组合 / 多孔材料 / 表界面工程 / 药物递送

Key words

combination products / porous materials / surface engineering / drug delivery

引用本文

导出引用
陈彦臣 , 钱泓霖 , 郭一蓉 , . 聚合物多孔表界面材料的构筑及给药应用*[J]. 化学进展. 2024, 36(5): 679-695 https://doi.org/10.7536/PC230919
, , , et al. Polymeric Porous Surface Materials: Construction and Drug Delivery Applications[J]. Progress in Chemistry. 2024, 36(5): 679-695 https://doi.org/10.7536/PC230919
中图分类号: O631    O647.11    R94 (药剂学)   

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基金

国家自然科学基金项目(U20A20262)
国家自然科学基金项目(51933009)
国家自然科学基金项目(52203190)
中央高校基本科研业务费专项资金(226-2023-00108)

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