Abbreviation (ISO4): Chinese Journal of Alzheimer's Disease and Related Disorders
Editor in chief: Jun WANG
Chinese Journal of Alzheimer's Disease and Related Disorders >
To analyse factors affecting decline in level of activities of daily living in patients with Alzheimer’s disease
Received date: 2019-11-08
Revised date: 2019-12-01
Online published: 2020-03-25
Objective: To analyze the factors influencing the decline of Ability of daily life in patients with mild to moderate Alzheimer’s disease. Methods: Sixty-four patients with mild to moderate Alzheimer’s disease were followed up for 16 weeks. MMSE, MoCA, ADCS-ADL and ADAS-cog were assessed at the beginning and after 16 weeks. Results: In the group without anti dementia drugs, MMSE score, MoCA score, ADCS-ADL score and ADAS-cog score were 20.50±3.53, 18.67±7.01, 17.50±11.73 and 45.17±4.28, respectively. After 16 weeks of observation, they were 18.25±6.23, 17.92±6.96, 18.67±12.23 and 43.67±7.72, respectively, all with deterioration trend, but there was no statistical significance before and after the observation; in the group treated with single anti dementia drug, the MMSE score, MoCA score, ADCS-ADL score and ADAS-cog score were 19.50±4.50, 17.30±5.47, 16.13±9.24 and 46.50±5.59, respectively, and they were 22.73±4.88, 17.83±6.34, 14.50±8.20 and 48.58±5.63 after 16 weeks of observation. There were significant differences in MMSE score, ADAS-cog score and ADCS-ADL score; The MMSE score, MoCA score, ADCS-ADL score and ADAS-cog score were 18.75±2.63, 18.58±5.02, 19.08±18.00 and 42.58±6.59 respectively in the combination group, and they were 24.83±6.22, 19.67±4.10, 16.42±15.54 and 48.00±5.83 respectively after 16 weeks of observation, the score was improved and the difference was statistically significant. Multiple linear regression analysis showed that education level, basic ADCS-ADL score, anti dementia treatment plan and care had influence on ADCS-ADL score (P<0.05). Conclusion: Early combination of anti dementia drugs and intensive care can improve the ability of daily life of AD patients, and education also plays a positive role.
XIAO Tianyi , WANG Hongquan , LI Yanfeng . To analyse factors affecting decline in level of activities of daily living in patients with Alzheimer’s disease[J]. Chinese Journal of Alzheimer's Disease and Related Disorders, 2020 , 3(1) : 37 -41 . DOI: 10.3969/j.issn.2096-5516.2020.01.010
表1 患者基线资料 |
组别 | 性别(男/女,例) | 年龄 | 受教育年限 | HAMD | 稳定照料(是/否,例) |
---|---|---|---|---|---|
未用药 | 3/9 | 69.92±13.99 | 10.92±4.10 | 2.33±2.61 | 6/6 |
单用药 | 8/32 | 71.63±9.76 | 12.30±3.38 | 3.70±5.63 | 30/10 |
联用药 | 4/8 | 71.58±8.13 | 13.50±4.25 | 4.50±3.21 | 11/1 |
P值 | 0.898 | 0.152 | 0.236 | 0.537 | 0.068 |
表2 各组入组前及16周后评分比较 |
MMSE | MoCA | ADAS-cog | ADCS-ADL | ||
---|---|---|---|---|---|
未用药 | 入组前 | 20.50±3.53 | 18.67±7.01 | 17.50±11.73 | 45.17±4.28 |
16周后 | 18.25±6.23 | 17.92±6.96 | 18.67±12.23 | 43.67±7.72 | |
前后比较P值 | 0.052 | 0.069 | 0.318 | 0.267 | |
单用药 | 入组前 | 19.50±4.50 | 17.30±5.47 | 16.13±9.24 | 46.50±5.59 |
16周后 | 22.73±4.88 | 17.83±6.34 | 14.50±8.20 | 48.58±5.63 | |
前后比较P值 | 0.000 | 0.248 | 0.000 | 0.008 | |
联用药 | 入组前 | 18.75±2.63 | 18.58±5.02 | 19.08±18.00 | 42.58±6.59 |
16周后 | 24.83±6.22 | 19.67±4.10 | 16.42±15.54 | 48.00±5.83 | |
前后比较P值 | 0.002 | 0.000 | 0.001 | 0.009 | |
组间比较P值 | 入组前 | 0.570 | 0.668 | 0.734 | 0.108 |
16周后 | 0.001 | 0.525 | 0.479 | 0.055 |
表3 变量的编号、定义、赋值及单位 |
编号 | 变量名称 | 定义、赋值及单位 |
---|---|---|
Y | 日常生活能力 下降分值 | 16周后ADCS-ADL评分-入组前ADCS-ADL评分,数值型 |
X1 | 性别 | 男1,女2 |
X2 | 年龄 | 数值型,岁 |
X3 | 受教育程度 | 数值型,年 |
X4 | 入组时MMSE评分 | 数值型,分 |
X5 | 入组时MoCA评分 | 数值型,分 |
X6 | 入组时ADAS-cog评分 | 数值型,分 |
X7 | 入组时ADCS-ADL评分 | 数值型,分 |
X8 | 抗痴呆治疗方案 | 未用药1,单用药2,联用药3 |
X9 | 照料 | 没有稳定的亲属照料1,有稳定的亲属照料2 |
表4 日常生活能力下降影响因素的多元线性回归分析结果 |
变量 | B | 标准误 | β | T值 | P值 |
---|---|---|---|---|---|
X3 | 0.239 | 0.115 | 0.214 | 2.072 | 0.043 |
X7 | 0.194 | 0.065 | 0.267 | 2.970 | 0.004 |
X8 | 2.792 | 0.595 | 0.416 | 4.692 | 0.000 |
X9 | 2.536 | 0.864 | 0.273 | 2.936 | 0.005 |
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