The Mechanism by Which the Gut Microbiota Affects the Occurrence and Development of Schizophrenia

Zhixia TAN, Yuanqi LIU, Linna YANG, Yi PENG, Biming ZHANG, Xiangli YE

Life Sci Res ›› 2025, Vol. 29 ›› Issue (5) : 406-412.

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Life Sci Res ›› 2025, Vol. 29 ›› Issue (5) : 406-412. DOI: 10.16605/j.cnki.1007-7847.2025.03.0126
BASIC MEDICINE

The Mechanism by Which the Gut Microbiota Affects the Occurrence and Development of Schizophrenia

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Abstract

The diversity, composition and functional capacity of the gut microbiota vary considerably among individuals, and these differences have been shown to be related to the occurrence and development of various diseases. Schizophrenia is the most serious, disabling, and devastating of all mental diseases, yet its etiology and pathogenesis remain poorly understood. This paper mainly discusses the correlation between intestinal microbes and schizophrenia, as well as the possible mechanisms of action, such as kynurenine metabolic pathway, synaptic plasticity, and infection and inflammation, so as to provide insights for the prevention and treatment of mental illnesses.

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gut microbiota / schizophrenia / kynurenine metabolic pathway / infection and inflammation / sy-naptic plasticity

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Zhixia TAN , Yuanqi LIU , Linna YANG , et al . The Mechanism by Which the Gut Microbiota Affects the Occurrence and Development of Schizophrenia[J]. Life Science Research. 2025, 29(5): 406-412 https://doi.org/10.16605/j.cnki.1007-7847.2025.03.0126

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