Research Progress of Helicobacter pylori-Associated Extragastric Diseases

Jinyang LIU, Zhenghong CHEN, Muxi MA, Yongshuai LIN, Weiwei TAN

Acta Academiae Medicinae Sinicae ›› 2024, Vol. 46 ›› Issue (3) : 414-424.

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Acta Academiae Medicinae Sinicae

Abbreviation (ISO4): Acta Academiae Medicinae Sinicae      Editor in chief: Xuetao CAO

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Acta Academiae Medicinae Sinicae ›› 2024, Vol. 46 ›› Issue (3) : 414-424. DOI: 10.3881/j.issn.1000-503X.15698
Review Articles

Research Progress of Helicobacter pylori-Associated Extragastric Diseases

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Abstract

Helicobacter pylori(Hp)is a common Gram-negative bacillus causing gastrointestinal infections.It mainly exists on the surface of gastric epithelial cells and in mucus and is associated with gastric ulcers,gastric cancer,and gastric mucosa-associated lymphomas.Studies have shown that Hp can induce or exacerbate certain extragastric diseases and is associated with the occurrence of coronavirus disease 2019.It is hypothesized that Hp may be indirectly or directly involved in the occurrence and development of diseases by stimulating the production of inflammatory cytokines or inducing cross-immune reactions.in addition,Hp can enter Candida to release toxins continuously and play a role in escaping the recognition of the host immune system and the bactericidal effect of drugs.This article reviews the research progress in Hp-associated extragastric diseases in recent years,aiming to draw the attention of clinical workers to Hp-associated extragastric diseases and enrich the knowledge about Hp infection for formulating countermeasures to avoid the aggravation or triggering of other diseases by Hp。

Key words

Helicobacter pylori / extragastric diseases / cross-immune reaction / coronavirus disease 2019

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Jinyang LIU , Zhenghong CHEN , Muxi MA , et al . Research Progress of Helicobacter pylori-Associated Extragastric Diseases[J]. Acta Academiae Medicinae Sinicae. 2024, 46(3): 414-424 https://doi.org/10.3881/j.issn.1000-503X.15698

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