Research Progress in the Anti-Inflammatory Effect of Exercise in Ameliorating Neuroinflammation-Related Depression

Zhixin ZHANG; Qi GUO; Xiaoyu CHEN

doi:10.3881/j.issn.1000-503X.15991

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Acta Academiae Medicinae Sinicae ›› 2025, Vol. 47 ›› Issue (2) : 191-197. DOI: 10.3881/j.issn.1000-503X.15991

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Research Progress in the Anti-Inflammatory Effect of Exercise in Ameliorating Neuroinflammation-Related Depression

Zhixin ZHANG ¹^,² ,
Qi GUO ¹ ,
Xiaoyu CHEN ¹

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Abstract

Depression is an affective disorder caused by multiple factors,and its pathogenesis is still unclear.However,in recent years,studies have found an association between neuroinflammation and depression,which is mainly reflected in the interaction of their pathogeneses,such as abnormalities of monoamine neurotransmitters in the brain,dysregulation of the hypothalamic-pituitary-adrenal axis,and dysfunction of neurogenesis.Currently,exercise as a therapy for depression has attracted widespread attention.By reviewing relevant research reports,this article summarizes that exercise alleviates neuroinflammation by playing an anti-inflammatory role,thus improving the mood-related pathway to treat depression.Furthermore,this article explores the effects of different exercise prescriptions on the anti-inflammatory role of exercise,aiming to provide new scientific ideas for the treatment of depression associated with neuroinflammation.

Key words

exercise / depression / neuroinflammation / anti-inflammatory / exercise prescription

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Zhixin ZHANG , Qi GUO , Xiaoyu CHEN. Research Progress in the Anti-Inflammatory Effect of Exercise in Ameliorating Neuroinflammation-Related Depression[J]. Acta Academiae Medicinae Sinicae. 2025, 47(2): 191-197 https://doi.org/10.3881/j.issn.1000-503X.15991

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