Research Progress in the Relationship Between Hyperhomocysteinemia and Chronic Kidney Disease

Congcong DING, Xiao HUANG, Huihui BAO, Xiaoshu CHENG

Acta Academiae Medicinae Sinicae ›› 2025, Vol. 47 ›› Issue (2) : 281-288.

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Abbreviation (ISO4): Acta Academiae Medicinae Sinicae      Editor in chief: Xuetao CAO

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Acta Academiae Medicinae Sinicae ›› 2025, Vol. 47 ›› Issue (2) : 281-288. DOI: 10.3881/j.issn.1000-503X.16112
Review Articles

Research Progress in the Relationship Between Hyperhomocysteinemia and Chronic Kidney Disease

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Abstract

In patients with chronic kidney disease(CKD),the incidence of cardiovascular events and the mortality rate are significantly higher than those in the general population.Approximately 85% of end-stage CKD patients develop hyperhomocysteinemia(HHcy)due to impaired renal function.It is not yet fully determined whether HHcy merely acts as a biomarker of CKD or plays a role in the pathogenesis.Although supplementation with folic acid and other B vitamins(B6 and B12)has been proven to lower the plasma level of total homocysteine,their effectiveness in slowing CKD progression or reducing cardiovascular complications remains uncertain.This article reviews the latest research progress in the relationship between HHcy and CKD,aiming to give new insights into the prevention and treatment of CKD and its complications.

Key words

chronic kidney disease / homocysteine / hyperhomocysteinemia / folic acid / vitamin

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Congcong DING , Xiao HUANG , Huihui BAO , et al. Research Progress in the Relationship Between Hyperhomocysteinemia and Chronic Kidney Disease[J]. Acta Academiae Medicinae Sinicae. 2025, 47(2): 281-288 https://doi.org/10.3881/j.issn.1000-503X.16112

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