Primary Non-Hodgkin Lymphoma in the Female Genital System: Report of Two Cases and Review of the Literature

Tianyu ZHANG; Li QIN; Dongyan CAO; Jiaxin YANG; Yi LIU; Tao WANG

doi:10.3881/j.issn.1000-503X.16116

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Acta Academiae Medicinae Sinicae ›› 2025, Vol. 47 ›› Issue (2) : 314-318. DOI: 10.3881/j.issn.1000-503X.16116

Case Reports

Primary Non-Hodgkin Lymphoma in the Female Genital System: Report of Two Cases and Review of the Literature

Tianyu ZHANG ¹ ,
Li QIN ² ,
Dongyan CAO ¹ ,
Jiaxin YANG ¹ ,
Yi LIU ² ,
Tao WANG ¹

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Abstract

Primary female genital system lymphoma(PFGSL)is a rare subtype of extranodal lymphoma and patients commonly present in the department of gynecology.At present,there is a lack of uniform standards for the treatment of PFGSL.Although the classification of lymphoid neoplasmas was updated by the World Health Organization classification of haematolymphoid tumors in 2016,PFGSL was still not elaborated in sufficient detail.Most cases of PFGSL are non-Hodgkin lymphoma,involving the ovary and cervix.In some cases,involvement of uterine corpus,vagina,and vulva is reported.In this article,we report two cases of non-Hodgkin lymphoma in the female genital system,one from the uterus and the other from the ovary.By presenting the diagnosis and treatment of the two cases and reviewing the literature,we aim to provide a reference for clinicians in recognizing and treating rare cases.

Key words

female genital system / non-Hodgkin lymphoma / treatment / prognosis

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Tianyu ZHANG , Li QIN , Dongyan CAO , et al . Primary Non-Hodgkin Lymphoma in the Female Genital System: Report of Two Cases and Review of the Literature[J]. Acta Academiae Medicinae Sinicae. 2025, 47(2): 314-318 https://doi.org/10.3881/j.issn.1000-503X.16116

References

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[1]	Nasioudis D, Kampaktsis PN, Frey M, et al. Primary lymphoma of the female genital tract:an analysis of 697 cases[J]. Gynecol Oncol, 2017, 145(2):305-309.DOI:10.1016/j.ygyno.2017.02.043. Cited in this article [4]

[2]	Peng F, Li J, Mu S, et al. Epidemiological features for primary lymphoma of the female genital tract patients and development of a nomogram to predict survival[J]. Ann Med, 2022, 54(1):962-976.DOI:10.1080/07853890.2022.2046289. Cited in this article [1]

[3]	Wei WX, Huang JJ, Wang Y, et al. Primary female genital system lymphoma:a single institution’s experience over 10 years[J]. Hematol Oncol, 2014, 32(3):162-164.DOI:10.1002/hon.2118. Cited in this article [3]

[4]	He M, Hu S, Luo H. Ultrasound diagnosis and clinicopathological traits of female genital system malignant lymphomas[J]. Medicine(Baltimore), 2020, 99(34):e21341.DOI:10.1097/md.0000000000021341. Cited in this article [1]

[5]	Weng X, Huang M, Zhang M, et al. Primary lymphoma of the uterine cervix:a clinicopathologic study of 13 cases with review of additional 54 cases in the literature[J]. Virchows Arch, 2023, 482(2):419-429.DOI:10.1007/s00428-022-03436-y. Cited in this article [1]

[6]	Moller MB, d’Amore F, Christensen BE. Testicular lymphoma:a population-based study of incidence,clinicopathological correlations and prognosis.The Danish Lymphoma Study Group,LYFO[J]. Eur J Cancer, 1994, 30A(12):1760-1764.DOI:10.1016/0959-8049(94)00311-r. Cited in this article [1]

[7]	Stabile G, Ripepi C, Sancin L, et al. Management of primary iterine cervix B-cell lymphoma stage IE and fertility sparing outcome:a systematic review of the literature[J]. Cancers(Basel), 2023, 15(14):3679.DOI:10.3390/cancers15143679. Cited in this article [3]

[8]

National Cancer Institute sponsored study of classifications of non-Hodgkin’s lymphomas:summary and description of a working formulation for clinical usage. The Non-Hodgkin’s Lymphoma Pathologic Classification Project[J]. Cancer, 1982, 49(10):2112-2135. DOI:10.1002/1097-0142(19820515)49:10<2112::aid-cncr2820491024>3.0.co;2-2.

Cited in this article [2]

[9]	Du E, Qu X, Xu W, et al. Primary female genital system lymphoma complicated by a recurrent mucinous borderline ovarian tumor:a case report and review of the literature[J]. BMC Womens Health, 2021, 21(1):420.DOI:10.1186/s12905-021-01568-y. Cited in this article [1]

[10]	Lagoo AS, Robboy SJ. Lymphoma of the female genital tract:current status[J]. Int J Gynecol Pathol, 2006, 25(1):1-21.DOI:10.1097/01.pgp.0000183049.30212.f9. Cited in this article [1]

[11]	Arshad I, Kafeel M. Primary endometrial diffuse large B-cell lymphoma:a rare disease and diagnostic challenge in an asymptomatic postmenopausal woman[J]. Cureus, 2022, 14(4):e24592.DOI:10.7759/cureus.24592. Cited in this article [1]

[12]	Capsa C, Calustian LA, Antoniu SA, et al. Primary non-Hodgkin uterine lymphoma of the cervix:a literature review[J]. Medicina(Kaunas), 2022, 58(1).DOI:10.3390/medicina58010106. Cited in this article [2]

[13]	Ahmad AK, Hui P, Litkouhi B, et al. Institutional review of primary non-hodgkin lymphoma of the female genital tract:a 33-year experience[J]. Int J Gynecol Cancer, 2014, 24(7):1250-1255.DOI:10.1097/IGC.0000000000000201. Cited in this article [4]

[14]	Paes FM, Kalkanis DG, Sideras PA, et al. FDG PET/CT of extranodal involvement in non-Hodgkin lymphoma and Hodgkin disease[J]. Radiographics, 2010, 30(1):269-291.DOI:10.1148/rg.301095088. Cited in this article [1]

[15]	Goksel S, Karaman E, Karacin P, et al. A rare localization of a common disease:primary uterine non-Hodgkin lymphoma mimicking leiomyosarcoma[J]. J Cancer Res Ther, 2022, 18(4):1205-1207.DOI:10.4103/jcrt.jcrt_435_22. Cited in this article [1]

[16]	Signorelli M, Maneo A, Cammarota S, et al. Conservative management in primary genital lymphomas:the role of chemotherapy[J]. Gynecol Oncol, 2007, 104(2):416-421.DOI:10.1016/j.ygyno.2006.08.024. Cited in this article [3]

[17]	Ren Y, Lin J, Chang B, et al. Clinical analysis of 57 cases of primary female genital system lymphoma[J]. China Oncology, 2020, 30(12):1002-1007.DOI:10.19401/j.cnki.1007-3639.2020.12.006. Cited in this article [3]

[18]	Stroh EL, Besa PC, Cox JD, et al. Treatment of patients with lymphomas of the uterus or cervix with combination chemotherapy and radiation therapy[J]. Cancer, 1995, 75(9):2392-2399.DOI:10.1002/1097-0142(19950501)75:9<2392::aid-cncr2820750932>3.0.co;2-y. Cited in this article [1]

[19]	Dursun P, Gultekin M, Bozdag G, et al. Primary cervical lymphoma:report of two cases and review of the literature[J]. Gynecol Oncol, 2005, 98(3):484-489.DOI:10.1016/j.ygyno.2005.04.040. Cited in this article [1]

[20]	Bhagat N, Kalkur P, Kalkur S. Primary non-Hodgkin’s lymphoma of the vagina(PNHLV):a gynaecologist’s enigma[J]. BMJ Case Rep, 2019, 12(5):e228544.DOI:10.1136/bcr-2018-228544. Cited in this article [1]

[21]	Cubo AM, Soto ZM, Cruz M, et al. Primary diffuse large B cell lymphoma of the uterine cervix successfully treated by combined chemotherapy alone:a case report[J]. Medicine(Baltimore), 2017, 96(19):e6846.DOI:10.1097/md.0000000000006846. Cited in this article [1]

[22]

Stabile

, Sancin

, Boschian

Bailo P

, et al. Hysteroscopic resection followed by adjuvant radiotherapy:report of a aew therapeutic approach to primary cervical diffuse large B-cell lymphoma[J]. Int J Environ Res Public Health, 2022, 19(18):11779.DOI:10.3390/ijerph191811779.

Cited in this article [1]