Hepatolenticular Degeneration With Primary Liver Cancer:Report of One Case and Review of the Literature

Hui WANG; Jialin DU; Qingya YANG; Diandian HAO; Mingyuan ZHANG; Xiaoyu WEN

doi:10.3881/j.issn.1000-503X.16152

PDF(680 KB)

Acta Academiae Medicinae Sinicae ›› 2025, Vol. 47 ›› Issue (2) : 319-324. DOI: 10.3881/j.issn.1000-503X.16152

Case Reports

Hepatolenticular Degeneration With Primary Liver Cancer:Report of One Case and Review of the Literature

Author information +

History +

Abstract

Hepatolenticular degeneration is a rare disease,and the number of cases of primary liver cancer occurring on the basis of liver cirrhosis caused by hepatolenticular degeneration is very small.This paper reports a case of hepatolenticular degeneration with primary liver cancer,and then reviews and summarizes current cases of this disease both domestically and internationally.

Key words

hepatolenticular degeneration / primary liver cancer / liver cirrhosis

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

Hui WANG , Jialin DU , Qingya YANG , et al . Hepatolenticular Degeneration With Primary Liver Cancer:Report of One Case and Review of the Literature[J]. Acta Academiae Medicinae Sinicae. 2025, 47(2): 319-324 https://doi.org/10.3881/j.issn.1000-503X.16152

References

List( Publishing order | Descend order by publishing year | Descend order by cited within ) Chart analysis

[1]	Merle U, Schaefer M, Ferenci P, et al. Clinical presentation,diagnosis and long-term outcome of Wilson’s disease:a cohort study[J]. Gut, 2007, 56(1):115-120.DOI:10.1136/gut.2005.087262. Cited in this article [1]

[2]	European Association For The Study Of The Liver. EASL clinical practice guidelines:Wilson’s disease[J]. J Hepatol, 2012, 56(3):671-685.DOI:10.1016/j.jhep.2011.11.007. Cited in this article [1]

[3]	Mulligan C, Bronstein JM. Wilson disease:an overview and approach to management[J]. Neurol Clin, 2020, 38(2):417-432.DOI:10.1016/j.ncl.2020.01.005. Cited in this article [1]

[4]	Ala A, Walker AP, Ashkan K, et al. Wilson’s disease[J]. Lancet, 2007, 369(9559):397-408.DOI:10.1016/S0140-6736(07)60196-2. Cited in this article [1]

[5]	Padilla CD, Therrell BL. Newborn screening in the Asia Pacific region[J]. J Inherit Metab Dis, 2007, 30(4):490-506.DOI:10.1007/s10545-007-0687-7. Cited in this article [1]

[6]	Michitaka K, Nishiguchi S, Aoyagi Y, et al. Etiology of liver cirrhosis in Japan:a nationwide survey[J]. J Gastroenterol, 2010, 45(1):86-94.DOI:10.1007/s00535-009-0128-5. Cited in this article [2]

[7]	Gunjan D, Nadda N, Kedia S, et al. Hepatocellular carcinoma:an unusual complication of longstanding Wilson disease[J]. J Clin Exp Hepatol, 2017, 7(2):152-154.DOI:10.1016/j.jceh.2016.09.012. Cited in this article [3]

[8]	张兰慧, 阎玉明, 黄建军. 肝豆状核变性合并原发性肝癌1例[J]. 中国中西医结合影像学杂志, 2013, 11(6):717.DOI:lO.3969/j.issn.1672-0512.2013.06.057. Cited in this article [2]

[9]	Thattil R, Dufour JF. Hepatocellular carcinoma in a non-cirrhotic patient with Wilson’s disease[J]. World J Gastroenterol, 2013, 19(13):2110-2113.DOI:10.3748/wjg.v19.i13.2110. Cited in this article [2]

[10]	Waqar M, Vohra AH. Hepatocellular carcinoma in a young man with resting and postural tremors[J]. Case Rep, 2013, 2013:bcr2013201198.DOI:10.1136/bcr-2013-201198. Cited in this article [2]

[11]	Vernadakis S, Moris D, Sotiropoulos GC. Liver transplantation for liver malignancies in Wilson’s disease:two novel cases[J]. Transplantation, 2014, 97(6):e35-e36.DOI:10.1097/TP.0000000000000026. Cited in this article [2]

[12]	Pfeiffenberger J, Mogler C, Gotthardt DN, et al. Hepatobiliary malignancies in Wilson disease[J]. Liver Int, 2015, 35(5):1615-1622.DOI:10.1111/liv.12727. Cited in this article [9]

[13]	Rosencrantz RA, Lecompte L, Yusuf Y. Beneath the copper—pediatric Wilson’s disease cirrhosis and hepatocellular carcinoma:a case report with literature review[J]. Semin Liver Dis, 2015, 35(4):434-438.DOI:10.1055/s-0035-1567828. Cited in this article [2]

[14]	Nakagawa T, Chubachi S. A case of Wilson’s disease with psoriasis vulgaris,complicated with hepatocellular carcinoma and successfully treated with sorafenib[J]. Gan To Kagaku Ryoho, 2015, 42(9):1107-1109. Cited in this article [2]

[15]	李响, 蔡洁, 徐钰雯, 等. 肝豆状核变性合并肝细胞癌1例报告[J]. 临床肝胆病杂志, 2018, 34(9):1967-1971.DOI:lO.3969/j.issn.100l-5256.2018.09.027. Cited in this article [3]

[16]	Ohkoshi-Yamada M, Kamimura K, Kamimura H, et al. Rare complication of hepatocellular carcinoma in Wilson’s disease[J]. JGH Open, 2021, 5(10):1220-1222.DOI:10.1002/jgh3.12648. Cited in this article [2]

[17]	Kitahata S, Michitaka K, Kinebuchi M, et al. Renal cell carcinoma and hepatocellular carcinoma in a patient with Wilson’s disease:a case report[J]. Intern Med, 2024, 63(7):963-968.DOI:10.2169/internalmedicine.2056-23. Cited in this article [2]

[18]	Chang IJ, Hahn SH. The genetics of Wilson disease[J]. Handb Clin Neurol, 2017, 142:19-34.DOI:10.1016/B978-0-444-63625-6.00003-3. Cited in this article [1]

[19]	梁秀龄. 解读《肝豆状核变性的诊断与治疗指南》[J]. 中国现代神经疾病杂志, 2009, 9(3):212-215.DOI:lO.3969/j.issn.1672-6731.2009.03.003. Cited in this article [1]

[20]	Członkowska A, Litwin T, Dusek P, et al. Wilson disease[J]. Nat Rev Dis Primers, 2018, 4(1):21.DOI:10.1038/s41572-018-0018-3. Cited in this article [1]

[21]	Lin LJ, Wang DX, Ding NN, et al. Comprehensive analysis on clinical features of Wilson’s disease:an experience over 28 years with 133 cases[J]. Neurol Res, 2014, 36(2):157-163.DOI:10.1179/1743132813Y.0000000262. Cited in this article [1]

[22]	Zhong HJ, Sun HH, Xue LF, et al. Differential hepatic features presenting in Wilson disease-associated cirrhosis and hepatitis B-associated cirrhosis[J]. World J Gastroenterol, 2019, 25(3):378.DOI:10.3748/wjg.v25.i3.378. Cited in this article [1]

[23]	Roberts EA, Socha P. Wilson disease in children[J]. Handb Clin Neurol, 2017,142:141-156.DOI:10.1016/B978-0-444-63625-6.00012-4. Cited in this article [1]

[24]	Wilkinson ML, Portmann B, Williams R. Wilson’s disease and hepatocellular carcinoma:possible protective role of copper[J]. Gut, 1983, 24(8):767-771.DOI:10.1136/gut.24.8.767. Cited in this article [1]

[25]	Melia WM, Johnson PJ, Neuberger J, et al. Hepatocellular carcinoma in primary biliary cirrhosis:detection by α-fetoprotein estimation[J]. Gastroenterology, 1984, 87(3):660-663. Cited in this article [1]

[26]	Wee A, Ludwig J, Coffey JRRJ, et al. Hepatobiliary carcinoma associated with primary sclerosing cholangitis and chronic ulcerative colitis[J]. Hum Pathol, 1985, 16(7):719-726.DOI:10.1016/s0046-8177(85)80158-1. Cited in this article [1]

[27]	Yamane Y, Sakai K, Umeda T, et al. Suppressive effect of cupric acetate on DNA alkylation,DNA synthesis and tumorigenesis in the liver of dimethylnitrosamine-treated rats[J]. Gan, 1984, 75(12):1062-1069. Cited in this article [1]

[28]	Kamamoto Y, Makiura S, Sugihara S, et al. The inhibitory effect of copper on DL-ethionine carcinogenesis in rats[J]. Cancer Res, 1973, 33(5):1129-1135. Cited in this article [1]

[29]	Stohs SJ, Bagchi D. Oxidative mechanisms in the toxicity of metal ions[J]. Free Radic Biol Med, 1995, 18(2):321-336.DOI:10.1016/0891-5849(94)00159-h. Cited in this article [1]

[30]	Britton RS. Metal-induced hepatotoxicity[J]. Semin Liver Dis, 1996, 16(1):3-12.DOI:10.1055/s-2007-1007214. Cited in this article [1]

[31]	Sheline CT, Choi DW. Cu2+toxicity inhibition of mitochondrial dehydrogenases in vitro and in vivo[J]. Ann Neurol, 2004, 55(5):645-653.DOI:10.1002/ana.20047. Cited in this article [1]

[32]	Sheline CT. Thiamine supplementation attenuated hepatocellular carcinoma in the Atp7b mouse model of Wilson’s disease[J]. Anticancer Res, 2011, 31(10):3395-3399. Cited in this article [1]

[33]	Cheng WS, Govindarajan S, Redeker AG. Hepatocellular carcinoma in a case of Wilson’s disease[J]. Liver, 1992, 12(1):42-45.DOI:10.1111/j.1600-0676.1992.tb00553.x. Cited in this article [1]