
Advances in the Localization and Regulation of P-glycoprotein in Different Tissues and Organs
Jiahua ZHAO, Xiaosa YANG, Xiaojiao XU, Rui LIU, Tiantian ZHUANG, Jiatang ZHANG
Acta Academiae Medicinae Sinicae ›› 2025, Vol. 47 ›› Issue (2) : 295-302.
Abbreviation (ISO4): Acta Academiae Medicinae Sinicae
Editor in chief: Xuetao CAO
Advances in the Localization and Regulation of P-glycoprotein in Different Tissues and Organs
P-glycoprotein(P-gp)is an ATP-dependent efflux transporter that is distributed in many tissues and organs.P-gp can selectively pump endogenous substrates and exogenous chemicals from the cell to the outside of the cell to maintain a stable endo-environment.However,it meanwhile restricts the entry of therapeutic drug into tissues and organs,and in particular,mediates the multidrug resistance of tumor cells to chemotherapeutic drugs.Therefore,understanding the localization of P-gp in different tissues and organs may be an important breakthrough point for disease treatment.In this paper,we mainly review the molecular structure,transport mechanism,localization,and regulation of P-gp in different tissues and organs,providing reference for the subsequent treatment of diseases.
P-glycoprotein / molecular structure / transport mechanism / localization / regulation
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