Research Progress in Effect of Repetitive Noxious Stimuli in Neonatal Period on Neural Development

LI Yan; ZHANG Wenyu; XIAO Zhi; LIU Xingfeng

doi:10.3881/j.issn.1000-503X.16266

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Acta Academiae Medicinae Sinicae ›› 0 DOI: 10.3881/j.issn.1000-503X.16266

Research Progress in Effect of Repetitive Noxious Stimuli in Neonatal Period on Neural Development

LI Yan¹, ZHANG Wenyu^1,2, XIAO Zhi^3,4,5, LIU Xingfeng^3,4,5

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Abstract

The establishment and development of neonatal intensive care unit(NICU)have significantly increased the survival rate of premature infants.However,the diagnosis,treatment,and surgeries performed in NICU may expose neonates to more noxious stimuli.As the neonatal period is crucial for brain development,these noxious stimuli may cause irreversible damage to the neonatal nervous system.Existing clinical studies have shown that repetitive noxious stimuli during the neonatal period can lead to poor brain development,persistent hyperalgesia,and various sequelae.However,the underlying mechanisms remain unclear,and effective treatment methods are lacking.This article summarizes the effects of repetitive noxious stimuli during the neonatal period on neural development and the complications,aiming to provide a basis for the neonatal analgesia management and the prevention and treatment of related sequelae.

Key words

pain / hyperalgesia / repetitive noxious stimuli / neonate / synaptic remodeling

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LI Yan, ZHANG Wenyu, XIAO Zhi, LIU Xingfeng. Research Progress in Effect of Repetitive Noxious Stimuli in Neonatal Period on Neural Development[J]. Acta Academiae Medicinae Sinicae. 0 https://doi.org/10.3881/j.issn.1000-503X.16266

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