Association Between Gastroesophageal Reflux Disease and the Risk of Incident Chronic Obstructive Pulmonary Disease

Ye LIAO; Yunfeng ZHOU; Xiaorui ZHOU; Xin HU; Juan LIAO; Lu LONG

doi:10.3881/j.issn.1000-503X.16279

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Acta Academiae Medicinae Sinicae ›› 2025, Vol. 47 ›› Issue (3) : 402-407. DOI: 10.3881/j.issn.1000-503X.16279

Original Articles

Association Between Gastroesophageal Reflux Disease and the Risk of Incident Chronic Obstructive Pulmonary Disease

Ye LIAO ¹ ,
Yunfeng ZHOU ² ,
Xiaorui ZHOU ¹ ,
Xin HU ³ ,
Juan LIAO ⁴ ,
Lu LONG ¹

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Abstract

Objective To investigate the association between gastroesophageal reflux disease(GERD)and the risk of incident chronic obstructive pulmonary disease(COPD)and explore potential effect modifiers influencing this association.Methods Clinical data from 476 175 participants in the UK Biobank(2006-2010)were collected.A Cox proportional hazards model was used to assess the relationship between GERD and the risk of incident COPD.Subgroup analyses were conducted to examine potential modifiers of the primary findings.Results A total of 11 587(2.43%)new COPD cases were diagnosed.The Cox proportional hazards model revealed that GERD was associated with an increased risk of incident COPD(HR=1.59,95%CI=1.46-1.74,P<0.001).GERD was linked to a higher risk of incident COPD in individuals aged<60 years(P<0.001)and non-smokers(P=0.011).No association was observed between GERD and the risk of incident COPD in current smokers with a daily cigarette consumption<10 cigarettes(P=0.261).Conclusion GERD may increase the risk of incident COPD.

Key words

gastroesophageal reflux disease / chronic obstructive pulmonary disease / prospective study

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Ye LIAO , Yunfeng ZHOU , Xiaorui ZHOU , et al . Association Between Gastroesophageal Reflux Disease and the Risk of Incident Chronic Obstructive Pulmonary Disease[J]. Acta Academiae Medicinae Sinicae. 2025, 47(3): 402-407 https://doi.org/10.3881/j.issn.1000-503X.16279

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