Research Progress of Photoacoustic Imaging in the Precision Diagnosis and Treatment of Thyroid Carcinoma

Jiaojiao MA; Xuehua XI; Yang DU; Bo ZHANG

doi:10.3881/j.issn.1000-503X.16349

PDF(847 KB)

Acta Academiae Medicinae Sinicae ›› 2025, Vol. 47 ›› Issue (3) : 447-451. DOI: 10.3881/j.issn.1000-503X.16349

Review Articles

Research Progress of Photoacoustic Imaging in the Precision Diagnosis and Treatment of Thyroid Carcinoma

Jiaojiao MA ¹^,²^,³ ,
Xuehua XI ¹^,² ,
Yang DU ⁴^,⁵ ,
Bo ZHANG ¹^,²^,³

Author information +

History +

Abstract

The incidence of thyroid cancer keeps rising globally,with the majority being papillary thyroid carcinoma (PTC),which has a favorable prognosis.However,some aggressive PTCs exhibit different clinical behaviors and higher mortality risks,with the growth rate surpassing that of well-differentiated PTC and undifferentiated cancers.Therefore,achieving precise diagnosis and treatment of thyroid carcinoma presents a significant challenge.Photoacoustic imaging is a molecular imaging technology that integrates optical imaging and ultrasound,providing imaging information on structure,function,and molecules.Moreover,it can utilize exogenous contrast agents to realize tumor treatment,such as photothermal therapy,serving as a promising technology for precise diagnosis and treatment of thyroid carcinoma.Researchers both domestically and internationally have explored the application of photoacoustic imaging in the precise diagnosis and treatment of thyroid tumors.This article reviews the research progress,elucidates the advantages and limitations of photoacoustic imaging in the diagnosis and treatment of thyroid carcinoma,and prospects on the precise diagnosis and treatment of this disease.

Key words

thyroid carcinoma / photoacoustic imaging / precision diagnosis and treatment / molecular imaging

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

Jiaojiao MA , Xuehua XI , Yang DU , et al. Research Progress of Photoacoustic Imaging in the Precision Diagnosis and Treatment of Thyroid Carcinoma[J]. Acta Academiae Medicinae Sinicae. 2025, 47(3): 447-451 https://doi.org/10.3881/j.issn.1000-503X.16349

References

List( Publishing order | Descend order by publishing year | Descend order by cited within ) Chart analysis

[1]	Pizzato M, Li M, Vignat J, et al. The epidemiological landscape of thyroid cancer worldwide:GLOBOCAN estimates for incidence and mortality rates in 2020[J]. Lancet Diabetes Endocrinol, 2022, 10(4):264-272.DOI:10.1016/S2213-8587(22)00035-3. Cited in this article [1]

[2]	Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2024, 74(3):229-263.DOI:10.3322/caac.21834. Cited in this article [1]

[3]	Lloyd RV, Osamura RY, Kloppel G, et al. WHO classification of tumours:pathology and genetics of tumours of endocrine organs[M]. 4th ed. Lyon: IARC Press, 2017. Cited in this article [1]

[4]	Shi X, Liu R, Basolo F, et al. Differential clinicopathological risk and prognosis of major papillary thyroid cancer variants[J]. J Clin Endocrinol Metab, 2016, 101(1):264-274.DOI:10.1210/jc.2015-2917. Cited in this article [1]

[5]	Cartwright S, Fingeret A. Contemporary evaluation and management of tall cell variant of papillary thyroid carcinoma[J]. Curr Opin Endocrinol Diabetes Obes, 2020, 27(5):351-357.DOI:10.1097/MED.0000000000000559. Cited in this article [1]

[6]	Ho AS, Luu M, Barrios L, et al. Incidence and mortality risk spectrum across aggressive variants of papillary thyroid carcinoma[J]. JAMA Oncol, 2020, 6(5):706-713.DOI:10.1001/jamaoncol.2019.6851. Cited in this article [1]

[7]	James ML, Gambhir SS. A molecular imaging primer:modalities,imaging agents,and applications[J]. Physiol Rev, 2012, 92(2):897-965.DOI:10.1152/physrev.00049.2010. Cited in this article [2]

[8]	Steinberg I, Huland DM, Vermesh O, et al. Photoacoustic clinical imaging[J]. Photoacoustics. 2019, 14:77-98.DOI:10.1016/j.pacs.2019.04.001. Cited in this article [4]

[9]	Karlas A, Pleitez MA, Aguirre J, et al. Optoacoustic imaging in endocrinology and metabolism[J]. Nat Rev Endocrinol, 2021, 17(6):323-335.DOI:10.1038/s41574-021-00482-5. Cited in this article [1]

[10]

Haugen

, Alexander

, Bible

, et al. 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer:The American Thyroid Association Guidelines Task Force on thyroid nodules and differentiated thyroid cancer[J]. Thyroid, 2016, 26 (1):1-133.DOI:10.1089/thy.2015.0020.

Cited in this article [1]

[11]	Shin JH, Baek JH, Chung J, et al. Ultrasonography diagnosis and imaging-based management of thyroid nodules:Revised Korean Society of Thyroid Radiology Consensus Statement and Recommendations[J]. Korean J Radiol, 2016, 17(3):370-395.DOI:10.3348/kjr.2016.17.3.370. Cited in this article [1]

[12]	Russ G, Bonnema SJ, Erdogan MF, et al. European Thyroid Association Guidelines for ultrasound malignancy risk stratification of thyroid nodules in adults:The EU-TIRADS[J]. Eur Thyroid J, 2017, 6(5):225-237.DOI:10.1159/000478927. Cited in this article [1]

[13]	Tessler FN, Middleton WD, Grant EG, et al. ACR Thyroid Imaging,Reporting and Data System (TI-RADS):white paper of the ACR TI-RADS Committee[J]. J Am Coll Radiol, 2017, 14(5):587-595.DOI:10.1016/j.jacr.2017.01.046. Cited in this article [1]

[14]	Dogra VS, Chinni BK, Valluru KS, et al. Preliminary results of ex vivo multispectral photoacoustic imaging in the management of thyroid cancer[J]. AJR Am J Roentgenol, 2014, 202(6):W552-W558.DOI:10.2214/AJR.13.11433. Cited in this article [1]

[15]	Yang M, Zhao L, He X, et al. Photoacoustic/ultrasound dual imaging of human thyroid cancers:an initial clinical study[J]. Biomed Opt Express, 2017, 8(7):3449-3457.DOI:10.1364/BOE.8.003449. Cited in this article [1]

[16]	Dima A, Ntziachristos V. In-vivo handheld optoacoustic tomography of the human thyroid[J]. Photoacoustics. 2016, 4(2):65-69.DOI:10.1016/j.pacs.2016.05.003. Cited in this article [1]

[17]	Roll W, Markwardt NA, Masthoff M, et al. Multispectral optoacoustic tomography of benign and malignant thyroid disorders:a pilot study[J]. J Nucl Med, 2019, 60(10):1461-1466.DOI:10.2967/jnumed.118.222174. Cited in this article [2]

[18]	Kim J, Park B, Ha J, et al. Multiparametric photoacoustic analysis of human thyroid cancers in vivo[J]. Cancer Res, 2021, 81(18):4849-4860.DOI:10.1158/0008-5472.CAN-20-3334. Cited in this article [2]

[19]	曲恩泽, 戴志飞, 王淑敏, 等. 自制超声/荧光双功能造影剂在兔正常淋巴结中的显像[J]. 中国医学科学院学报, 2013, 35(4):411-415.DOI:10.3881/j.issn.1000-503X.2013.04.010. Cited in this article [1]

[20]	Wu Y, Zeng F, Zhao Y, et al. Emerging contrast agents for multispectral optoacoustic imaging and their biomedical applications[J]. Chem Soc Rev, 2021, 50(14):7924-7940.DOI:10.1039/d1cs00358e. Cited in this article [1]

[21]	Weber J, Beard PC, Bohndiek SE. Contrast agents for molecular photoacoustic imaging[J]. Nat Methods, 2016, 13(8):639-650.DOI:10.1038/nmeth.3929. Cited in this article [1]

[22]	Karthikesh MS, Yang X. Photoacoustic image-guided interventions[J]. Exp Biol Med (Maywood), 2020, 245(4):330-341.DOI:10.1177/1535370219889323 Cited in this article [1]

[23]	Ma X, Li X, Shi J, et al. Host-guest polypyrrole nanocomplex for three-stimuli-responsive drug delivery and imaging-guided chemo-photothermal synergetic therapy of refractory thyroid cancer[J]. Adv Healthc Mater, 2019, 8(17):e1900661.DOI:10.1002/adhm.201900661. Cited in this article [2]

[24]	Zhang Z, Wang L, Wang J, et al. Mesoporous silica-coated gold nanorods as a light-mediated multifunctional theranostic platform for cancer treatment[J]. Adv Mater, 2012, 24(11):1418-1423.DOI:10.1002/adma.201104714. Cited in this article [1]

[25]	Xi D, Xiao M, Cao J, et al. NIR light-driving barrier-free group rotation in nanoparticles with an 88.3% photothermal conversion efficiency for photothermal therapy[J]. Adv Mater, 2020, 32(11):e1907855.DOI:10.1002/adma.201907855. Cited in this article [1]

[26]	Peng J, Chen F, Liu Y, et al. A light-driven dual-nanotransformer with deep tumor penetration for efficient chemo-immunotherapy[J]. Theranostics, 2022, 12(4):1756-1768.DOI:10.7150/thno.68756. Cited in this article [1]

[27]	Liu Y, Yu B, Dai X, et al. Biomineralized calcium carbonate nanohybrids for mild photothermal heating-enhanced gene therapy[J]. Biomaterials, 2021,274:120885.DOI:10.1016/j.biomaterials.2021.120885. Cited in this article [1]

[28]	Lin L, Wang LV. The emerging role of photoacoustic imaging in clinical oncology[J]. Nat Rev Clin Oncol, 2022, 19(6):365-384.DOI:10.1038/s41571-022-00615-3. Cited in this article [2]

[29]	Liu H, Teng X, Yu S, et al. Recent advances in photoacoustic imaging:current status and future perspectives[J]. Micromachines(Basel), 2024, 15(8):1007.DOI:10.3390/mi15081007. Cited in this article [1]