Advances in the Studies of MicroRNA-1976 in Aberrant Cell Cycle Diseases

Haoyu JI, Hao CHEN, Liang SHI, Meng ZHANG, Ting CHEN, Yingming KONG, Rongke FENG

Acta Academiae Medicinae Sinicae ›› 2025, Vol. 47 ›› Issue (4) : 644-650.

PDF(1017 KB)
Home Journals Acta Academiae Medicinae Sinicae
Acta Academiae Medicinae Sinicae

Abbreviation (ISO4): Acta Academiae Medicinae Sinicae      Editor in chief: Xuetao CAO

About  /  Aim & scope  /  Editorial board  /  Indexed  /  Contact  / 
PDF(1017 KB)
Acta Academiae Medicinae Sinicae ›› 2025, Vol. 47 ›› Issue (4) : 644-650. DOI: 10.3881/j.issn.1000-503X.16376
Review Articles

Advances in the Studies of MicroRNA-1976 in Aberrant Cell Cycle Diseases

Author information +
History +

Abstract

Most tumor cells and healthy neurons are at rest during G0 phase.Once the cell cycle is abnormally re-entered under certain conditions,the proliferation of tumor cells and the degenerative necrosis of neurons can be initiated.From the perspective of the cell cycle,cancer and central nervous system diseases,two seemingly different disease types,have a common pathogenesis.This type of diseases is named aberrant cell cycle diseases.As a newly discovered microRNA(miR),miR-1976 is closely related to the regulation of the cell cycle.This review summarizes the progress in the research on miR-1976 in cancer and central nervous system diseases,aiming to provide a reference for the clinical application of miR-1976 in aberrant cell cycle diseases in the future.

Key words

microRNA-1976 / aberrant cell cycle / cancer / central nervous system disease

Cite this article

Download Citations
Haoyu JI , Hao CHEN , Liang SHI , et al . Advances in the Studies of MicroRNA-1976 in Aberrant Cell Cycle Diseases[J]. Acta Academiae Medicinae Sinicae. 2025, 47(4): 644-650 https://doi.org/10.3881/j.issn.1000-503X.16376

References

[1]
Yano S, Zhang Y, Miwa S, et al. Spatial-temporal FUCCI imaging of each cell in a tumor demonstrates locational dependence of cell cycle dynamics and chemoresponsiveness[J]. Cell Cycle, 2014, 13(13):2110-2119.DOI:10.4161/cc.29156.
[2]
Li X, Cao G, Liu X, et al. Polymerases and DNA repair in neurons:implications in neuronal survival and neurodegenerative diseases[J]. Front Cell Neurosci, 2022,16:852002.DOI:10.3389/fncel.2022.852002.
[3]
Liu DZ, Ander BP. Cell cycle inhibition without disruption of neurogenesis is a strategy for treatment of aberrant cell cycle diseases:an update[J]. Sci World J, 2012,2012:491737.DOI:10.1100/2012/491737.
[4]
Lee RC, Feinbaum RL, Ambros V. The C.elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14[J]. Cell, 1993, 75(5):843-854.DOI:10.1016/0092-8674(93)90529-y.
[5]
Lagos-Quintana M, Rauhut R, Lendeckel W, et al. Identification of novel genes coding for small expressed RNAs[J]. Science, 2001, 294(5543):853-858.DOI:10.1126/science.1064921.
[6]
Seyhan AA. Circulating microRNAs as potential biomarkers in pancreatic cancer-advances and challenges[J]. Int J Mol Sci, 2023, 24(17):13340.DOI:10.3390/ijms241713340.
[7]
Lewis BP, Burge CB, Bartel DP. Conserved seed pairing,often flanked by adenosines,indicates that thousands of human genes are microRNA targets[J]. Cell, 2005, 120(1):15-20.DOI:10.1016/j.cell.2004.12.035.
[8]
Chen G, Hu J, Huang Z, et al. MicroRNA-1976 functions as a tumor suppressor and serves as a prognostic indicator in non-small cell lung cancer by directly targeting PLCE1[J]. Biochem Biophys Res Commun, 2016, 473(4):1144-1151.DOI:10.1016/j.bbrc.2016.04.030.
[9]
Matthews HK, Bertoli C, de Bruin RAM. Cell cycle control in cancer[J]. Nat Rev Mol Cell Biol, 2022, 23(1):74-88.DOI:10.1038/s41580-021-00404-3.
[10]
Calin GA, Sevignani C, Dumitru CD, et al. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers[J]. Proc Natl Acad Sci U S A, 2004, 101(9):2999-3004.DOI:10.1073/pnas.0307323101.
[11]
Wang J, Li M, Han X, et al. MiR-1976 knockdown promotes epithelial-mesenchymal transition and cancer stem cell properties inducing triple-negative breast cancer metastasis[J]. Cell Death Dis, 2020, 11(7):500.DOI:10.1038/s41419-020-2711-x.
[12]
Shi Q, Xu G, Jiang Y, et al. Phospholipase PLCE1 promotes transcription and phosphorylation of MCM7 to drive tumor progression in esophageal cancer[J]. Cancer Res, 2024, 84(4):560-576.DOI:10.1158/0008-5472.Can-23-1633.
[13]
Huang P, Zhao H, Sun R, et al. MiR-1976/NCAPH/P65 axis inhibits the malignant phenotypes of lung adenocarcinoma[J]. Sci Rep, 2024, 14(1):11211.DOI:10.1038/s41598-024-61261-6.
[14]
李珊, 张颖辉, 王志芳, 等. LINC00243靶向miR-1976促进甲状腺癌细胞增殖、迁移和侵袭[J]. 现代肿瘤医学, 2021, 29(22):3902-3908.DOI:10.3969/j.issn.1672-4992.2021.22.004.
[15]
Mishra S, Yadav T, Rani V. Exploring miRNA based approaches in cancer diagnostics and therapeutics[J]. Crit Rev Oncol Hematol, 2016, 98(2):12-23.DOI:10.1016/j.critrevonc.2015.10.003.
[16]
Sahu SS, Dey S, Nabinger SC, et al. The role and therapeutic potential of miRNAs in colorectal liver metastasis[J]. Sci Rep, 2019, 9(1):15803.DOI:10.1038/s41598-019-52225-2.
[17]
Latchana N, Abrams ZB, Howard JH, et al. Plasma microRNA levels following resection of metastatic melanoma[J]. Bioinform Biol Insights, 2017,11:1177932217694837.DOI:10.1177/1177932217694837.
[18]
Bhadra T, Mallik S, Sohel A, et al. Unsupervised feature selection using an integrated strategy of hierarchical clustering with singular value decomposition:an integrative biomarker discovery method with application to acute myeloid leukemia[J]. IEEE/ACM Trans Comput Biol Bioinform, 2022, 19(3):1354-1364.DOI:10.1109/tcbb.2021.3110989.
[19]
Lee TY, Tseng CJ, Wang JW, et al. Anti-microRNA-1976 as a novel approach to enhance chemosensitivity in XAF1(+) pancreatic and liver cancer[J]. Biomedicines, 2023, 11(4):1136.DOI:10.3390/biomedicines11041136.
[20]
Wang J, Ma G, Han X, et al. The low expression of miR-1976 in plasma samples indicating its biological functions in the progression of breast cancer[J]. Clin Transl Oncol, 2020, 22(11):2111-2120.DOI:10.1007/s12094-020-02361-3.
[21]
Wang Y, Xu M, Yang Q. A six-microRNA signature predicts survival of patients with uterine corpus endometrial carcinoma[J]. Curr Probl Cancer, 2019, 43(2):167-176.DOI:10.1016/j.currproblcancer.2018.02.002.
[22]
Xin G, Cao X, Zhao W, et al. MicroRNA expression profile and TNM staging system predict survival in patients with lung adenocarcinoma[J]. Math Biosci Eng, 2020, 17(6):8074-8083.DOI:10.3934/mbe.2020409.
[23]
Diener C, Keller A, Meese E. Emerging concepts of miRNA therapeutics:from cells to clinic[J]. Trends Genet, 2022, 38(6):613-626.DOI:10.1016/j.tig.2022.02.006.
[24]
Khameneh SC, Razi S, Lashanizadegan R, et al. MicroRNA-mediated metabolic regulation of immune cells in cancer:an updated review[J]. Front Immunol, 2024,15:1424909.DOI:10.3389/fimmu.2024.1424909.
[25]
D’Arpa P, Beardmore C, Liu LF. Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons[J]. Cancer Res, 1990, 50(21):6919-6924.
[26]
Vaxevanis C, Bachmann M, Seliger B. Immune modulatory microRNAs in tumors,their clinical relevance in diagnosis and therapy[J]. J Immunother Cancer, 2024, 12(8):e009774.DOI:10.1136/jitc-2024-009774.
[27]
Kim SY, Choi HG, Kim YH, et al. Longitudinal study of the inverse relationship between Parkinson’s disease and cancer in Korea[J]. NPJ Parkinsons Dis, 2023, 9(1):116.DOI:10.1038/s41531-023-00562-5.
[28]
Oh J, Lee HS, Jeon S, et al. Marked reduction in the risk of dementia in patients with breast cancer:a nationwide population-based cohort study[J]. Cancer Res Treat, 2023, 55(2):551-561.DOI:10.4143/crt.2022.272.
[29]
Tacik P, Curry S, Fujioka S, et al. Cancer in Parkinson’s disease[J]. Parkinsonism Relat Disord, 2016, 31(10):28-33.DOI:10.1016/j.parkreldis.2016.06.014.
[30]
Ibáñez K, Boullosa C, Tabarés-Seisdedos R, et al. Molecular evidence for the inverse comorbidity between central nervous system disorders and cancers detected by transcriptomic meta-analyses[J]. PLoS Genet, 2014, 10(2):e1004173.DOI:10.1371/journal.pgen.1004173.
[31]
Li JM, Liu C, Hu X, et al. Inverse correlation between Alzheimer’s disease and cancer:implication for a strong impact of regenerative propensity on neurodegeneration[J]. BMC Neurol, 2014,14:211.DOI:10.1186/s12883-014-0211-2.
[32]
Calegari F, Huttner WB. An inhibition of cyclin-dependent kinases that lengthens,but does not arrest,neuroepithelial cell cycle induces premature neurogenesis[J]. J Cell Sci, 2003, 116(Pt 24):4947-4955.DOI:10.1242/jcs.00825.
[33]
Marlier Q, D’Aes T, Verteneuil S, et al. Core cell cycle machinery is crucially involved in both life and death of post-mitotic neurons[J]. Cell Mol Life Sci, 2020, 77(22):4553-4571.DOI:10.1007/s00018-020-03548-1.
[34]
Kurita M, Kuwajima T, Nishimura I, et al. Necdin downregulates CDC2 expression to attenuate neuronal apoptosis[J]. J Neurosci, 2006, 26(46):12003-12013.DOI:10.1523/jneurosci.3002-06.2006.
[35]
侯一玮, 王洪财, 葛汝丽. 细胞周期G2/M期调控与神经变性疾病[J]. 国际神经病学神经外科学杂志, 2018, 45(3):320-323.DOI:10.16636/j.cnki.jinn.2018.03.024.
[36]
Vincent I, Jicha G, Rosado M, et al. Aberrant expression of mitotic cdc2/cyclin B1 kinase in degenerating neurons of Alzheimer’s disease brain[J]. J Neurosci, 1997, 17(10):3588-3598.DOI:10.1523/jneurosci.17-10-03588.1997.
[37]
Paccosi E, Proietti-De-Santis L. Parkinson’s disease:from genetics and epigenetics to treatment,a miRNA-based strategy[J]. Int J Mol Sci, 2023, 24(11):9547.DOI:10.3390/ijms24119547.
[38]
邱峰, 吴越, 曹辉, 等. 帕金森病异常表达microRNAs的筛选及microRNA-1976作用机制的初步研究[J]. 临床神经病学杂志, 2017, 30(3):171-174.
[39]
Qiu F, Wu Y, Xie G, et al. MiRNA-1976 regulates the apoptosis of dopaminergic neurons by targeting the PINK1 gene[J]. J Integr Neurosci, 2023, 22(2):45.DOI:10.31083/j.jin2202045.
[40]
Desideri E, Martins LM. Mitochondrial stress signalling:HTAR2 and Parkinson’s disease[J]. Int J Cell Biol, 2012,2012:607929.DOI:10.1155/2012/607929.
[41]
Pickles S, Vigié P, Youle RJ. Mitophagy and quality control mechanisms in mitochondrial maintenance[J]. Curr Biol, 2018, 28(4):R170-R185.DOI:10.1016/j.cub.2018.01.004.
[42]
O’Flanagan CH, Morais VA, Wurst W, et al. The Parkinson’s gene PINK1 regulates cell cycle progression and promotes cancer-associated phenotypes[J]. Oncogene, 2015, 34(11):1363-1374.DOI:10.1038/onc.2014.81.
[43]
谢涛波, 钟纯正, 符尧天. miR-1976在帕金森综合征中的作用[J]. 临床和实验医学杂志, 2018, 17(13):1378-1381.DOI:10.3969/j.issn.1671-4695.2018.13.010.
[44]
Han B, Chen Y, Song C, et al. Autophagy modulates the stability of Wee1 and cell cycle G2/M transition[J]. Biochem Biophys Res Commun, 2023, 677(40):63-69.DOI:10.1016/j.bbrc.2023.08.010.
[45]
Ghelli Luserna di Rorà A, Cerchione C, Martinelli G, et al. A,Cerchione C,Martinelli G,et al.A WEE1 family business:regulation of mitosis,cancer progression,and therapeutic target[J]. J Hematol Oncol, 2020, 13(1):126.DOI:10.1186/s13045-020-00959-2.
[46]
陈婷, 陈浩, 师亮, 等. 微小RNA-124和RNA-1976在帕金森病患者血清中的表达及临床价值[J]. 中华老年医学杂志, 2024, 43(1):23-28.DOI:10.3760/cma.j.issn.0254-9026.2024.01.005.
[47]
欧诒丹, 钟纯正, 高元杰, 等. 帕金森病患者血清miR-1976、GDF-15水平变化及与姿势步态异常型的关系[J]. 中风与神经疾病杂志, 2023, 40(5):406-410.DOI:10.19845/j.cnki.zfysjjbzz.2023.0096.
[48]
Liu DZ, Ander BP, Sharp FR. Cell cycle inhibition without disruption of neurogenesis is a strategy for treatment of central nervous system diseases[J]. Neurobiol Dis, 2010, 37(3):549-557.DOI:10.1016/j.nbd.2009.11.013.
[49]
Pekarek L, Torres-Carranza D, Fraile-Martinez O, et al. An overview of the role of microRNAs on carcinogenesis:a focus on cell cycle,angiogenesis and metastasis[J]. Int J Mol Sci, 2023, 24(8):7268.DOI:10.3390/ijms24087268.
[50]
Zhai P, Tong T, Wang X, et al. Nuclear miR-451a activates KDM7A and leads to cetuximab resistance in head and neck squamous cell carcinoma[J]. Cell Mol Life Sci, 2024, 81(1):282.DOI:10.1007/s00018-024-05324-x.
[51]
Qiu X, Danesh Yazdi M, Wang C, et al. Extracellular microRNAs associated with psychiatric symptoms in the Normative Aging Study[J]. J Psychiatr Res, 2024, 178(10):270-277.DOI:10.1016/j.jpsychires.2024.08.017.
[52]
俞雯雯, 张航, 葛卫红, 等. β-榄香烯诱导人脑胶质瘤U251细胞凋亡的机制研究[J]. 浙江中医药大学学报, 2014, 38(4):451-455,460.DOI:10.16466/j.issn1005-5509.2014.04.021.
PDF(1017 KB)

Accesses

Citation

Detail

Sections
Recommended

/