Isolated Adrenocorticotropic Hormone Deficiency:Report of Three Cases and Literature Review

Yuyang XIAO; Jiyan YANG; Binyu SUN; Fang WANG

doi:10.3881/j.issn.1000-503X.16386

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Acta Academiae Medicinae Sinicae ›› 2025, Vol. 47 ›› Issue (6) : 1045-1050. DOI: 10.3881/j.issn.1000-503X.16386

Case Reports

Isolated Adrenocorticotropic Hormone Deficiency:Report of Three Cases and Literature Review

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Abstract

Isolated adrenocorticotropic hormone(ACTH)deficiency(IAD)is a rare disease first reported by Steinberg from Japan in 1954,and there have been few clinical reports about IAD to date.IAD is characterized by secondary adrenal cortical insufficiency,low or absent cortisol production,normal or transiently reversible increases in secretion of pituitary hormones other than ACTH,no structural pituitary defects,and exclusion of ACTH deficiency caused by exogenous glucocorticoid use and postoperative pituitary adenoma.This paper retrospectively analyzes the clinical data of three adult patients with IAD and summarizes their clinical characteristics,aiming to improve clinical awareness of this rare disease.

Key words

isolated adrenocorticotropic hormone deficiency / adrenal cortical insufficiency / autoimmunity

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Yuyang XIAO , Jiyan YANG , Binyu SUN , et al. Isolated Adrenocorticotropic Hormone Deficiency:Report of Three Cases and Literature Review[J]. Acta Academiae Medicinae Sinicae. 2025, 47(6): 1045-1050 https://doi.org/10.3881/j.issn.1000-503X.16386

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