Macro-Aspartate Aminotransferase With Metabolic Dysfunction-Associated Fatty Liver Disease in Adults:Report of One Case

Xinyue LIU; Zilong WANG; Shuang XU; Nan WU; Rui HUANG

doi:10.3881/j.issn.1000-503X.16509

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Acta Academiae Medicinae Sinicae ›› 2025, Vol. 47 ›› Issue (6) : 1057-1062. DOI: 10.3881/j.issn.1000-503X.16509

Case Reports

Macro-Aspartate Aminotransferase With Metabolic Dysfunction-Associated Fatty Liver Disease in Adults:Report of One Case

Xinyue LIU ¹ ,
Zilong WANG ² ,
Shuang XU ³ ,
Nan WU ² ,
Rui HUANG ⁴

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Abstract

Macro-aspartate aminotransferase(AST)is a macro-enzyme formed by self-polymerization or binding to other serum components that are difficult to be cleared by the kidneys,resulting in an isolated elevation in serum AST.Macro-AST is a rare disease.In this report,a case with isolated AST elevation as the main manifestation is presented.The diagnosis of macro-AST was established by the polyethylene glycol precipitation assay.The comprehensive history and exclusion of other factors suggest that this case of macro-AST may be secondary to metabolic dysfunction-associated fatty liver disease.

Key words

liver / macro-aspartate aminotransferase / polyethylene glycol precipitation assay / non-alcoholic fatty liver disease

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Xinyue LIU , Zilong WANG , Shuang XU , et al . Macro-Aspartate Aminotransferase With Metabolic Dysfunction-Associated Fatty Liver Disease in Adults:Report of One Case[J]. Acta Academiae Medicinae Sinicae. 2025, 47(6): 1057-1062 https://doi.org/10.3881/j.issn.1000-503X.16509

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