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Research Advances of RNA N6-Methyladenosine Modification in Arsenic-Induced Multi-Organ Damage
Qian ZHANG, Jin MAN
Acta Academiae Medicinae Sinicae ›› 2025, Vol. 47 ›› Issue (6) : 1006-1014.
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Abbreviation (ISO4): Acta Academiae Medicinae Sinicae
Editor in chief: Xuetao CAO
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Research Advances of RNA N6-Methyladenosine Modification in Arsenic-Induced Multi-Organ Damage
Arsenic is a widespread carcinogen in the environment,and chronic arsenic exposure results in dysfunction or even cancer development of multiple organs,including the skin,liver,lung,brain,and ovary.RNA N6-methyladenosine(m6A)is a ubiquitous epigenetic modification of RNA in eukaryotes,regulating numerous physiological and pathological processes in cells.Increasing studies have shown that m6A plays a crucial role in arsenic-induced damage of multiple organs and systems,including the skin,liver,lung,nervous system,reproductive system,and embryo.This paper summarizes the recent studies on the regulatory role of m6A in arsenic-induced damage,providing new ideas and directions for the investigation of the mechanism and treatment strategy of arsenic toxicity.
RNA N6-methyladenosine / arsenic / RNA epigenetic modification / toxic mechanism
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