Kleine-Levin Syndrome Accompanied With Complex Headache:Report of One Case

Li ZHANG; Zunbo LI; Hua LIU; Xiaolin WANG; Ruozhuo LIU

doi:10.3881/j.issn.1000-503X.16650

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Acta Academiae Medicinae Sinicae ›› 2026, Vol. 48 ›› Issue (2) : 385-389. DOI: 10.3881/j.issn.1000-503X.16650

Case Reports

Kleine-Levin Syndrome Accompanied With Complex Headache:Report of One Case

Li ZHANG ¹^,² ,
Zunbo LI ² ,
Hua LIU ¹ ,
Xiaolin WANG ¹ ,
Ruozhuo LIU ¹

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Abstract

Kleine-Levin syndrome is an extremely rare sleep disorder.In addition to recurrent daytime sleepiness,symptoms such as overeating,hypersexuality,cognitive impairment,and mental and behavioral abnormalities usually occur.Hypothalamic dysfunction may be the underlying pathogenesis.Cases with headache are rare.We reported a case of Kleine-Levin syndrome with headache symptoms during narcolepsy,and his headache was characterized by both migraine and cluster headache.It is hypothesized that Kleine-Levin syndrome may have a potential common pathogenesis with functional headaches such as migraine or cluster headache,which may be related to hypothalamic dysfunction.

Key words

Kleine-Levin syndrome / narcolepsy / migraine / cluster headache / hypothalamus

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Li ZHANG , Zunbo LI , Hua LIU , et al . Kleine-Levin Syndrome Accompanied With Complex Headache:Report of One Case[J]. Acta Academiae Medicinae Sinicae. 2026, 48(2): 385-389 https://doi.org/10.3881/j.issn.1000-503X.16650

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