Molecular Mechanism and Application Progress of Circular RNA Regulating Ischemic Stroke Through the Competing Endogenous RNA Network

Tianpei WANG; Lili TENG; Minmin WU; Wenjing SONG; Hanwen MA; Luwen ZHU

doi:10.3881/j.issn.1000-503X.16778

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Acta Academiae Medicinae Sinicae ›› 2026, Vol. 48 ›› Issue (1) : 144-152. DOI: 10.3881/j.issn.1000-503X.16778

Molecular Mechanism and Application Progress of Circular RNA Regulating Ischemic Stroke Through the Competing Endogenous RNA Network

Tianpei WANG ¹ ,
Lili TENG ¹ ,
Minmin WU ¹ ,
Wenjing SONG ¹ ,
Hanwen MA ¹ ,
Luwen ZHU ²^,³

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Abstract

Ischemic stroke(IS)remains a predominant contributor to mortality and disability,with current clinical interventions demonstrating suboptimal therapeutic efficacy.Recent studies have shown that circular RNA(circRNA)participates in pathological processes through the competing endogenous RNA(ceRNA)regulatory network,involving key processes such as apoptosis,inflammatory response,angiogenesis,autophagy,oxidative stress,and neuronal regeneration.This study reviews the molecular mechanism and application progress of circRNA regulating IS through the ceRNA network,aiming to provide theoretical support for the in-depth development of circRNA in the diagnosis and treatment strategies of IS and offer guidance for future related research and clinical practice.

Key words

circular RNA / ischemic stroke / molecular mechanism / biomarker / targeted therapy

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Tianpei WANG , Lili TENG , Minmin WU , et al . Molecular Mechanism and Application Progress of Circular RNA Regulating Ischemic Stroke Through the Competing Endogenous RNA Network[J]. Acta Academiae Medicinae Sinicae. 2026, 48(1): 144-152 https://doi.org/10.3881/j.issn.1000-503X.16778

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