Clinical Characteristics of Hereditary and Sporadic Medullary Thyroid Carcinoma

doi:10.3881/j.issn.1000-503X.2012.04.017

PDF(635 KB)

Acta Academiae Medicinae Sinicae ›› 2012, Vol. 34 ›› Issue (4) : 401-404. DOI: 10.3881/j.issn.1000-503X.2012.04.017

Original Articles

Clinical Characteristics of Hereditary and Sporadic Medullary Thyroid Carcinoma

XU Lai, ZHAO Yu-pei, WANG Wei-bin, ZHANG Tai-ping, LIAO Quan, CHEN Ge, ZHOU Li, SHU Hong

Author information +

History +

Abstract

Objective To study the clinical characteristics and outcomes of the hereditary medullary thyroid carcinoma (HMTC) and the sporadic medullary thyroid carcinoma (SMTC). Methods The clinical data of 78 patients with medullary thyroid carcinoma who underwent surgery in our hospital between July 1980 and May 2011 were retrospectively analyzed. Results Of these 78 patients, there were 23 HMTC cases and 55 SMTC cases. The HMTC group was significantly younger age of onset [(36.4±13.5) years vs. (46.6±11.2) years, P<0.01] and a lower pre/post-operative serum calcitonin levels [(850.4±110.20) ng/L vs. (1450.4±118.3) ng/L, P<0.01 and (410.8±133.2) ng/L vs. (1585.4±129.5) ng/L, P<0.01] than the SMTC group. In addition, the mean tumor diameter was also significantly smaller in the HMTC group (14.3 mm vs. 21.0 mm in SMTC group, P<0.05). Tumor multifocality was seen in a significantly higher proportion of HMTC cases compared with the SMTC cases (56.6% vs. 29.1%, P<0.05). The overall 10-year survival was 100% in HMTC group and 80.2% in SMTC group (P<0.05). Conclusion HMTC has a better prognosis than SMTC.

Key words

tyriod neoplasms

/ medullary thyroid carcinoma / hereditary / multiple endocrine neoplasia 2

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

XU Lai,ZHAO Yu-pei,WANG Wei-bin,ZHANG Tai-ping,LIAO Quan,CHEN Ge,ZHOU Li,SHU Hong. Clinical Characteristics of Hereditary and Sporadic Medullary Thyroid Carcinoma[J]. Acta Academiae Medicinae Sinicae. 2012, 34(4): 401-404 https://doi.org/10.3881/j.issn.1000-503X.2012.04.017

References

［1］Gilliland FD, Hunt WC, Morris DM, et al. Prognosticv factors for thyroid carcinoma: a population-based study of 15,698 cases from the Surveillance, Epidemiology and End Results (SEER) program, 1973-1991 ［J］. Cancer, 1997, 79(3):564-573.

［2］Brandi ML, Gagel RF, Angeli A, et al. Guidelines for diagnosis and therapy of MEN type 1 and type 2 ［J］. J Clin Endocrinol Metab, 2001, 86(12):5658-5671.

［3］Gimm O, Sutter T, Dralle H. Diagnosis and therapy of sporadic and familial medullary throid carcinoma ［J］. J Cancer Res Clin Oncol, 2001, 127(3):156-165.

［4］Mulligan LM, Kwok JB, Healey CS, et al. Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A ［J］. Nature, 1993, 363(6428):458-460.

［5］Sobin LH, Wittekind CH. UICC: TNM classification of malignant tumors ［M］. New York: Wiley-Liss, 2002.

［6］Raue F, Kotzerke J, Reinwein D, et al. Prognostic factora in medullary thyroid carcinoma: evalution of 741 patients from the German Medullary Thyroid Carcinoma Register ［J］. Clin Investig, 1993, 71(1):7-12.

［7］Steiner AL, Goodman AD, Powers SR, et al. Study of a kindred with pheochromocytoma, medullary thyroid carcinoma,hyperparathymidism and Cushings disease: multiple endocrine neoplasia,type 2 ［J］. Medicine(Baltimore), 1968, 47(5):371-409.

［8］Abraham DT, Low TH, Messina M, et al. Medullary thyroid carcinoma: long-term outcomes of surgical treatment ［J］. Ann Surg Oncol, 2011, 18(1):219-225.

［9］蔡胜，欧阳云淑，李健初，等. 超声对甲状腺髓样癌的诊断价值［J］. 中国超声医学杂志，2008, 24(12):1071-1075.

［10］Collins BT, Cramer HM, Tabatowski K, et al. Fine-needle aspiration of medullary carcinoma of the thyroid. Cytomorphology, immunocytochemistry, and electron microscopy ［J］. Acta Cytol, 1995, 39(5):920-930.

［11］Hyer SL, Vini L, AHern R, et al. Medullary thyroid cancer: multivariate analysis of prognostic factors influencing survival ［J］. Eur J Surg Oncol, 2000, 26(7):686-690.

［12］Lundgren CI, Delbridg L, Learoyd D, et al. Surgical approach to medullary thyoid cancer ［J］. Arq Bras Endocrinol Metabol, 2007, 51(5):818-824.

［13］Moo-Young TA, Traugott AL, Moley JF. Sporadic and familial medullary thyroid carcinoma: state of the art ［J］. Surg Clin North Am, 2009, 89(5):1193-1204.

［14］张再兴，李正江，唐平章, 等. 甲状腺髓样癌的外科治疗及预后分析［J］. 中华耳鼻喉头颈外科杂志, 2011, 46(3):209-213.