Application of New Separation and Purification Technology in Natural Products

Wenwei Li; Ziyu Zhu; Ruilin Haotian; Yao Xie; Aiqin Luo; Axin Liang

doi:10.7536/PC230809

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Prog Chem ›› 2024, Vol. 36 ›› Issue (5) : 667-678. DOI: 10.7536/PC230809

Review

Application of New Separation and Purification Technology in Natural Products

Wenwei Li ¹ ,
Ziyu Zhu ¹ ,
Ruilin Haotian ¹ ,
Yao Xie ²^,^* ,
Aiqin Luo ¹^,^* ,
Axin Liang ¹^,^*

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History +

Abstract

natural products are secondary metabolites preserved by natural selection in the long-term evolution process of natural organisms,and are widely used in many fields because of their rich medicinal value.With the development of modern science,the demand for high purity products of natural products is also increasing.Traditional separation methods usually have some disadvantages such as large consumption of organic solvents,poor separation effect,high cost and long cycle,which seriously restrict the development and use of natural products in various fields.the emergence of new separation and purification technology provides a new idea for the extraction,separation and application of natural products.On the basis of summarizing the existing literature,this paper reviews the new methods of separation and purification of natural products,and finally summarizes and discusses the research bottleneck and future development direction of natural product separation and purification。

Contents

1 Introduction

2 Novel chromatographic method

2.1 Counter-current chromatography

2.2 Hydrophilic interaction chromatography

3 Supercritical fluid separation

3.1 Ionic liquid separation

3.2 Deep eutectic solvent separation

3.3 Ionic liquid and deep eutectic solvent cooperation

4 Molecular imprinting technology

4.1 Magnetic molecularly imprinted polymer

4.2 Molecular imprinted solid phase extraction

4.3 Deep eutectic solvent-molecularly imprinted polymer

5 Conclusion and outlook

Key words

natural products / separation / purification

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Wenwei Li , Ziyu Zhu , Ruilin Haotian , et al . Application of New Separation and Purification Technology in Natural Products[J]. Progress in Chemistry. 2024, 36(5): 667-678 https://doi.org/10.7536/PC230809

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Funding

National Key R&D Program of China(2019YFA0904104)

Scientific Research Cooperation Program(202221641061A)

Scientific Research Cooperation Program(202321641067A)

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