Research on the Reaction of N，N-Dimethylformamide （DMF） as Synthons

Mina Zhao; Jiayi Tang; Yaodu Zhang

doi:10.7536/PC20250504

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Prog Chem ›› 2025, Vol. 37 ›› Issue (11) : 1661-1673. DOI: 10.7536/PC20250504

Review

Research on the Reaction of N，N-Dimethylformamide （DMF） as Synthons

Mina Zhao ¹^,^* ,
Jiayi Tang ¹ ,
Yaodu Zhang ²

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Abstract

N，N-dimethylformamide （DMF） is a common organic compound. It is not only often used as a solvent in organic reactions but also widely employed as a reaction reagent in industrial production， playing an important role in organic synthesis for a long time. It is worth noting that DMF itself can act as a synthon to provide different structural units for participation in organic synthesis reactions， and it plays a very important role in the construction of complex， diverse and structurally novel functional molecules. Therefore， this review focuses on introducing the performance of DMF as a multifunctional precursor in various reactions， summarizes the latest progress of DMF as an amine source， carbon source， hydrogen source， oxygen source and double synthon reactions， and prospects the future development direction of this field， hoping to provide a reference for the later research on reactions involving DMF as a synthon.

Contents

1 Introduction

2 Reaction of DMF as a synthon

2.1 Reaction of DMF as an amine source

2.2 Reaction of DMF as a carbon source

2.3 Reaction with DMF as a hydrogen source

2.4 Reaction of DMF as an oxygen source

2.5 DMF as a double synthon

3 Conclusion and outlook

Key words

N，N-dimethylformamide / synthon / transformation / mechanism / dual function

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Mina Zhao , Jiayi Tang , Yaodu Zhang. Research on the Reaction of N，N-Dimethylformamide （DMF） as Synthons[J]. Progress in Chemistry. 2025, 37(11): 1661-1673 https://doi.org/10.7536/PC20250504

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