Home Diagnosis of Myocardial Infarction: Aptamer-Based cTnI Sensing Technology

Zhiyuan Xu, Guowei Gao, Yansheng Li, Qingwei Liao, Jingfang Hu, Xueji Zhang

Prog Chem ›› 2023, Vol. 35 ›› Issue (8) : 1266-1274.

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Prog Chem ›› 2023, Vol. 35 ›› Issue (8) : 1266-1274. DOI: 10.7536/PC221213
Review

Home Diagnosis of Myocardial Infarction: Aptamer-Based cTnI Sensing Technology

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Abstract

Cardiac troponin I (cTnI) is a biomarker closely associated with acute myocardial infarction (AMI) and is considered as the "gold standard" for the diagnosis of AMI. A variety of cTnI detection techniques have been developed, including antibody-based and aptamer-based detection methodology. Aptamers are short DNA or RNA sequences that can specifically bind to the target, and have been used in the development of cTnI detection platforms due to their advantages of good stability, easy synthesis and low cost. In this paper, cTnI detection methods are divided into optical detection and electrochemical detection according to the signal transduction mode. This review introduces the current research progress of aptamer-based cTnI sensing technology, describes the detection principle, performance, advantages and disadvantages of various methods, summarizes cTnI sensing technology and prospects its development in home testing, hoping to provide reference for the development of more sensitive and portable cTnI sensors.

Contents

1 Introduction

2 Optical detection

2.1 Fluorescence detection method

2.2 Surface-enhanced Raman scattering

2.3 Electrochemical luminescence method

3 Electrochemical detection

3.1 Electrochemical impedance spectrum

3.2 Differential pulse voltammetry

3.3 Square wave voltammetry

4 Conclusion and outlook

Key words

cardiac troponin I / aptamer / home testing / electrochemistry

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Zhiyuan Xu , Guowei Gao , Yansheng Li , et al . Home Diagnosis of Myocardial Infarction: Aptamer-Based cTnI Sensing Technology[J]. Progress in Chemistry. 2023, 35(8): 1266-1274 https://doi.org/10.7536/PC221213

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Funding

National Natural Science Foundation of China(62101053)
R&D Program of Beijing Municipal Education Commission(KM202211232004)
Fundamental Research Funds for the Central Public Welfare Research Institutes(RXRC2022001)
Project of Construction and Support for high-level Innovative Teams of Beijing Municipal Institutions(BPHR20220124)
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