Application of Nanozymes in the Treatment of Brain Diseases

Ziying Meng; Jie Wang; Jiapu Wang; Yan Wei; Di Huang; Ziwei Liang

doi:10.7536/PC230507

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Prog Chem ›› 2024, Vol. 36 ›› Issue (1) : 18-26. DOI: 10.7536/PC230507

Review

Application of Nanozymes in the Treatment of Brain Diseases

Ziying Meng ¹ ,
Jie Wang ¹ ,
Jiapu Wang ¹ ,
Yan Wei ¹^,² ,
Di Huang ¹^,² ,
Ziwei Liang ¹^,²^,^*

Author information +

History +

Abstract

In recent years, nanozymes, as a new generation of artificial enzymes, have gradually entered the medical field due to their multi-enzyme activity, high stability and targeting ability, which are superior to natural enzymes. Moreover, nanozymes have been applied to the treatment of a variety of diseases and cancer because of their regulatory effect on reactive oxygen species. Brain diseases, as one of the highest mortality diseases, are prone to produce complex inflammatory responses due to excessive reactive oxygen species in the pathological environment. Therefore, the application of nanozymes in the brain environment may become an effective means of monitoring and treatment of brain diseases. This article reviews the principles of nanozymes in the treatment of brain diseases and the current research status in this field in recent years, including nanozymes inducing cancer cell death by regulating the level of reactive oxygen species, nanozymes assisting traditional anticancer therapy, nanozymes using membrane proteins to monitor brain cancer, and their applications in traumatic brain injury, stroke, brain degenerative diseases, cerebral malaria and epilepsy. At the end of this text, the problems of its application in clinical treatment are discussed.

Contents

1 Introduction

2 Development of researches about nanozymes

3 Application of nanozymes in the treatment of brain cancer and brain diseases

3.1 Nanozymes in brain cancer

3.2 Nanozymes in degenerative disease

3.3 Nanozymes in other brain diseases

4 Conclusion and outlook

Key words

nanozymes / ROS / brain cancer / brain injury / Alzheimer’s disease

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Ziying Meng , Jie Wang , Jiapu Wang , et al . Application of Nanozymes in the Treatment of Brain Diseases[J]. Progress in Chemistry. 2024, 36(1): 18-26 https://doi.org/10.7536/PC230507

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