Iron-Blocking Antibacterial Agents Based on Gallium Salts or Gallium Porphyrins

Hao Zhang; Lei Zhang; Zhiyong Wang; Xinyu Zhou; Ruixiao Gao

doi:10.7536/PC240106

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Prog Chem ›› 2024, Vol. 36 ›› Issue (9) : 1392-1400. DOI: 10.7536/PC240106

Review

Iron-Blocking Antibacterial Agents Based on Gallium Salts or Gallium Porphyrins

Hao Zhang ¹^,² ,
Lei Zhang ² ,
Zhiyong Wang ¹ ,
Xinyu Zhou ¹ ,
Ruixiao Gao ¹^,^*

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Abstract

Interfering with bacterial iron metabolism is a non-antibiotic antibacterial strategy that is not easy to cause bacterial resistance.in this review,firstly,an iron-blocking antibacterial therapy which can kill drug-resistant bacteria but not easily cause drug resistance is introduced.Then,the mechanism of iron-blocking antibacterial therapy is explained from the iron uptake pathway and heme uptake pathway of bacteria.in addition,the types,in vitro antibacterial properties,and In vivo therapeutic effects of the iron blocking antimicrobials based on gallium salts and gallium porphyrins are reviewed in detail.Finally,the future development and practical application of the antimicrobials based on iron-blocking mechanism are prospected。

Contents

1 Introduction

2 Iron-blocking antibacterial mechanism

2.1 Host iron restriction for bacteria

2.2 Iron acquisition by bacteria

2.3 Iron-blocking antibacterial mechanism of gallium ion

2.4 Iron-blocking antibacterial mechanism of gallium porphyrins

3 Iron-blocking agents

3.1 Gallium salts

3.2 Gallium porphyrins

3.3 Combination of gallium ions and gallium porphyrins

4 Conclusion and outlook

Key words

drug resistance / gallium nitrate / gallium porphyrins / iron-blocking antibacterial therapies

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Hao Zhang , Lei Zhang , Zhiyong Wang , et al . Iron-Blocking Antibacterial Agents Based on Gallium Salts or Gallium Porphyrins[J]. Progress in Chemistry. 2024, 36(9): 1392-1400 https://doi.org/10.7536/PC240106

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