Microfluidic-Based Vasculatures on Chip: Methods and Recent Progress

Fangtian Wang; Liang Zhao; Guangsheng Guo; Xiayan Wang

doi:10.7536/PC240121

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Prog Chem ›› 2024, Vol. 36 ›› Issue (6) : 840-850. DOI: 10.7536/PC240121

Review

Microfluidic-Based Vasculatures on Chip: Methods and Recent Progress

Fangtian Wang ¹ ,
Liang Zhao ¹ ,
Guangsheng Guo ¹^,² ,
Xiayan Wang ¹^,^*

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Abstract

Microvasculature-on-a-chip,utilizing microfluidic technology,has emerged as a significant in vitro tool for simulating both the normal and disease states of blood vessel networks.in our review,we highlight the efficacy of microfluidic platforms in accurately reproducing the microenvironment of human blood vessels.we outline a range of methodologies employed to fabricate vascular networks in vitro,focusing on the use of endothelial cells within microfluidic structures.for each method,we provide an assessment of recent examples,critically evaluating their strengths and drawbacks.Furthermore,we delve into the outlook and the innovative advancements anticipated for next-generation vascular-on-a-chip models and the broader field of chip-based tissue engineering.

Contents

1 Introduction

2 The microfluidic approaches for recapitulating the vascular structure in vitro。

2.1 Monolayer-based culturing of the endothelial cells directly in the microfluidic device。

2.2 Hydrogel-based casting and fabricating of the lumen structure。

2.3 Mold or fugitive hydrogel sacrificially generates the endothelial lumen。

2.4 Self-assembling-based vascular network embedded in the hydrogel。

3 The conclusion and prospects

Key words

endothelial cells / microfluidic / micro-physiological system / microvasculature networks

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Fangtian Wang , Liang Zhao , Guangsheng Guo , et al. Microfluidic-Based Vasculatures on Chip: Methods and Recent Progress[J]. Progress in Chemistry. 2024, 36(6): 840-850 https://doi.org/10.7536/PC240121

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