Clinical Application Value of Exosomes and Research Progress on Exosome Detection based on Surface-Enhanced Raman Spectroscopy

Xinyu Liu; Xinyue Gu; Xiaoyuhao Jin; Jingjing Zhang; Lianhui Wang; Chunyuan Song

doi:10.7536/PC240804

Prog Chem ›› 2025, Vol. 37 ›› Issue (6) : 812-826. DOI: 10.7536/PC240804

Review

Clinical Application Value of Exosomes and Research Progress on Exosome Detection based on Surface-Enhanced Raman Spectroscopy

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Abstract

Since exosomes were discovered in sheep reticulocytes， more and more studies have shown that the function and characteristics of exosomes are closely related to the occurrence and development of diseases. The analysis and detection of exosomes have clinical significance for the diagnosis， treatment and prognosis of diseases. In recent years， researchers have taken advantage of surface-enhanced Raman spectroscopy （SERS） technology and developed a variety of strategies for high-sensitive， specific and multivariate detection of various biological information of exosomes. The SERS-based exosome detection technology shows a good application prospect in clinical medical diagnosis and treatment. This review summarizes the basic characteristics and main physiological mechanisms of exosomes， and discusses their clinical significance， correlation with diseases， related indicators for characterizing and difficulties in detection， and then focuses on the research progress of SERS detections of exosomes in the aspects of concentration， phenotype， content analysis， etc.， as well as the summary and prospect at the end.

Contents

1 Introduction

2 Exosome

2.1 Clinical significance

2.2 Correlation with disease

2.3 Clinical diagnostic significance and difficulties of concentration analysis， surface phenotype and contents detection

3 SERS detection for exosomes

3.1 Overview of SERS

3.2 Concentration analysis

3.3 Phenotype analysis

3.4 SERS combined with other analytical techniques

4 Conclusion and outlook

Key words

exosomes / surface-enhanced Raman spectroscopy （SERS） / clinical diagnosis / disease detection

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Xinyu Liu , Xinyue Gu , Xiaoyuhao Jin , et al . Clinical Application Value of Exosomes and Research Progress on Exosome Detection based on Surface-Enhanced Raman Spectroscopy[J]. Progress in Chemistry. 2025, 37(6): 812-826 https://doi.org/10.7536/PC240804

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National Natural Science Foundation of China(62235008)

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