Construction and Application of ONOO- Small Molecule Fluorescent Probes in Pathophysiological Processes

Ting Ma; Chunyu Deng; Jie Li; Zhouyu Wang; Qian Zhou; Xiaoqi Yu

doi:10.7536/PC240815

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Prog Chem ›› 2025, Vol. 37 ›› Issue (4) : 519-535. DOI: 10.7536/PC240815

Review

Construction and Application of ONOO^- Small Molecule Fluorescent Probes in Pathophysiological Processes

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Abstract

ONOO^-，produced by the diffusion-controlled reaction of nitric oxide and superoxide radicals，is a strong oxidizing and nitrating agent that causes damage to DNA，proteins，and other biomolecules in cells. Since ONOO^- is characterized by its short lifetime，high reactivity，and low concentration under physiological conditions，and the pathophysiological roles it plays in biological systems are not yet fully understood，it is of great significance to develop highly sensitive and selective detection technologies to achieve real-time dynamic monitoring of ONOO^-. In this paper，we review the research progress of ONOO^- fluorescent probes in disease-related processes in the recent 5 years，revealing the potential role of ONOO^- in various diseases，such as inflammation，tumors，liver injury，and brain diseases. Finally，the bottlenecks in the development of ONOO^- probes and future trends are discussed，which will promote the application of ONOO^- probes in chemistry，biology，and pharmacology.

Contents

1 Introduction

2 Design strategies of ONOO^- fluorescent probe

3 Detection and imaging of ONOO^- by fluorescent probes in disease-related processes

3.1 Detection and imaging of ONOO^- in inflammation

3.2 Detection and imaging of ONOO^- in tumors

3.3 Detection and imaging of ONOO^- in liver injuries

3.4 Detection and imaging of ONOO^- in brain diseases

3.5 Detection and imaging of ONOO^- in other disease models

4 Conclusion and outlook

Key words

fluorescence imaging / peroxynitrite / tumor / liver injury / neurodegenerative disease

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Ting Ma , Chunyu Deng , Jie Li , et al . Construction and Application of ONOO^- Small Molecule Fluorescent Probes in Pathophysiological Processes[J]. Progress in Chemistry. 2025, 37(4): 519-535 https://doi.org/10.7536/PC240815

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