Application of Porphyrin-Based Covalent Organic Frameworks in Tumor Therapy

Jiaxin Mao; Lu Zhao; Yunfeng Bai; Feng Feng

doi:10.7536/PC241003

PDF(10095 KB)

Prog Chem ›› 2025, Vol. 37 ›› Issue (7) : 978-988. DOI: 10.7536/PC241003

Review

Application of Porphyrin-Based Covalent Organic Frameworks in Tumor Therapy

Jiaxin Mao ¹ ,
Lu Zhao ¹ ,
Yunfeng Bai ¹^,²^,^* ,
Feng Feng ¹^,^*

Author information +

History +

Abstract

Covalent organic frameworks （COFs）， as a new class of functional organic materials， have attracted extensive attention since they were first proposed in 2005. In recent years， the application in biology is particularly prominent. Porphyrin-based COFs exhibit excellent advantages， such as high crystallinity， high porosity， flexible design， easy to surface modification and so on. These remarkable features enable them to serve as carriers of various therapeutic agents for drug delivery. Due to their special structure， such as the extended conjugate structure and the strong π-π packing interaction， porphyrin-based COFs exhibit a strong absorption effect in the visible region， have excellent thermal stability and chemical stability. In addition， they can be used as photosensitizers， so they have wide application potential in tumor therapy. This article focuses on the research progress of monotherapy and combination therapy based on porphyrin-based COFs for tumor. Finally， the challenges and prospects of their preparation and application in tumor therapy are discussed.

Contents

1 Introduction

2 Por-COFs in monotherapy

2.1 Photothermal therapy （PTT） of tumor

2.2 Photodynamic therapy （PDT） of tumor

2.3 Sonodynamic therapy （SDT） of tumor

3 Por-COFs in combined therapy

3.1 Por-COFs in dual-mode therapy

3.2 Por-COFs in trimodality therapy

4 Conclusion and outlook

Key words

porphyrin-based covalent organic frameworks / tumor therapy / monotherapy / combined therapy

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

Jiaxin Mao , Lu Zhao , Yunfeng Bai , et al. Application of Porphyrin-Based Covalent Organic Frameworks in Tumor Therapy[J]. Progress in Chemistry. 2025, 37(7): 978-988 https://doi.org/10.7536/PC241003

References

List( Publishing order | Descend order by publishing year | Descend order by cited within ) Chart analysis

[1]

Rock

C L

, Thomson

C A

, Sullivan

K R

, Howe

C L

, Kushi

L H

, Caan

B J

, Neuhouser

M L

, Bandera

E V

, Wang

, Robien

, Basen-Engquist

K M

, Brown

J C

, Courneya

K S

, Crane

T E

, Garcia

D O

, Grant

B L

, Hamilton

K K

, Hartman

S J

, Kenfield

S A

, Martinez

M E

, Meyerhardt

J A

, Nekhlyudov

, Overholser

, Patel

A V

, Pinto

B M

, Platek

M E

, Rees-Punia

, Spees

C K

, Gapstur

S M

, McCullough

M L

. CA A Cancer J. Clin., 2022, 72(3): 230.

Cited in this article [1]

[2]	Liu J, Wickramaratne N P, Qiao S Z, Jaroniec M. Nat. Mater., 2015, 14(8): 763. Cited in this article [1]

[3]	Côté A P, Benin A I, Ockwig N W, O'Keeffe M, Matzger A J, Yaghi O M. Science, 2005, 310(5751): 1166. Cited in this article [2]

[4]	Yaghi O M, Li G M, Li H L. Nature, 1995, 378(6558): 703. Cited in this article [1]

[5]	Huang H Y, Jiang R M, Feng Y L, Ouyang H, Zhou N G, Zhang X Y, Wei Y. Nanoscale, 2020, 12(3): 1325. Cited in this article [1]

[6]	Dai Y L, Xu C, Sun X L, Chen X Y. Chem. Soc. Rev., 2017, 46(12): 3830. Cited in this article [1]

[7]	Fan W P, Yung B, Huang P, Chen X Y. Chem. Rev., 2017, 117(22): 13566. Cited in this article [1]

[8]	Guan X, Yin H H, Xu X H, Xu G, Zhang Y, Zhou B G, Yue W W, Liu C, Sun L P, Xu H X, Zhang K. Adv. Funct. Mater., 2020, 30(27): 2000326. Cited in this article [1]

[9]	Li M, Lin H M, Qu F Y. Chem. Eng. J., 2020, 384: 123374. Cited in this article [1]

[10]	Lv K X, Lin H M, Qu F Y. Chem. Eng. J., 2020, 392: 124555. Cited in this article [1]

[11]	Diercks C S, Yaghi O M. Science, 2017, 355(6328): eaal1585. Cited in this article [1]

[12]	Xu H, Tao S S, Jiang D L. Nat. Mater., 2016, 15(7): 722. Cited in this article [1]

[13]	Halder A, Karak S, Addicoat M, Bera S, Chakraborty A, Kunjattu S H, Pachfule P, Heine T, Banerjee R. Angew. Chem., Int. Ed., 2018, 57(20): 5797. Cited in this article [1]

[14]	Zhang J, Han X, Wu X W, Liu Y, Cui Y. J. Am. Chem. Soc., 2017, 139(24): 8277. Cited in this article [1]

[15]	Huang N, Chen X, Krishna R, Jiang D L. Angew. Chem., Int. Ed., 2015, 54(10): 2986. Cited in this article [1]

[16]	Lin Y X, Deng Y, Wang M H, Zhou T C, Wang L, Ma J H, Yang J. Talanta, 2023, 253: 124043. Cited in this article [1]

[17]	Guan Q, Zhou L L, Li W Y, Li Y A, Dong Y B. Chem. Eur. J., 2020, 26(25): 5583. Cited in this article [1]

[18]	Li W Y, Wan J J, Kan J L, Wang B, Song T, Guan Q, Zhou L L, Li Y A, Dong Y B. Chem. Sci., 2023, 14(6): 1453. Cited in this article [1]

[19]	Das P, Mandal S K. Chem. Mater., 2019, 31(5): 1584. Cited in this article [1]

[20]	Ding S Y, Gao J, Wang Q, Zhang Y, Song W G, Su C Y, Wang W. J. Am. Chem. Soc., 2011, 133(49): 19816. Cited in this article [1]

[21]	Ascherl L, Evans E W, Gorman J, Orsborne S, Bessinger D, Bein T, Friend R H, Auras F. J. Am. Chem. Soc., 2019, 141(39): 15693. Cited in this article [1]

[22]	Vitaku E, Gannett C N, Carpenter K L, Shen L X, Abruña H D, Dichtel W R. J. Am. Chem. Soc., 2020, 142(1): 16. Cited in this article [1]

[23]	Fang Q R, Wang J H, Gu S, Kaspar R B, Zhuang Z B, Zheng J, Guo H X, Qiu S L, Yan Y S. J. Am. Chem. Soc., 2015, 137(26): 8352. Cited in this article [1]

[24]	Feng X, Chen L, Dong Y P, Jiang D L. Chem. Commun., 2011, 47(7): 1979. Cited in this article [1]

[25]	Abbas M, Zou Q L, Li S K, Yan X H. Adv. Mater., 2017, 29(12): 1605021. Cited in this article [1]

[26]	Chen Y, Li L, Chen W, Chen H, Yin J. Chin. Chem. Lett., 2019, 30(7): 1353. Cited in this article [1]

[27]	Ma H C, Zhao C C, Chen G J, Dong Y B. Nat. Commun., 2019, 10: 3368. Cited in this article [1]

[28]	Sun Q Q, Tang K, Song L Q, Li Y H, Pan W, Li N, Tang B. Biomater. Sci., 2021, 9(23): 7977. Cited in this article [3]

[29]	Wan X Y, Zhang J, Zuo K M, Zhang H W, Hu H, Pan W, Gao Y N, Li N, Tang B. Sci. China Mater., 2023, 66(3): 1227. Cited in this article [3]

[30]	Tong S M, Li C, Wang K, Wu F S. Mater. Chem. Front., 2024, 8(5): 1390. Cited in this article [1]

[31]	Kundu S, Behera B, Giri A, Saha N T, Patra A. Chem. Commun., 2021, 57(56): 6875. Cited in this article [1]

[32]	Miao Y Y, Lv S B, Zheng D Y, Liu Y H, Liu D P, Song F L. Biomater. Sci., 2021, 9(7): 2533. Cited in this article [1]

[33]	Zhang Y, Zhang L, Wang Z Z, Wang F M, Kang L H, Cao F F, Dong K, Ren J S, Qu X G. Biomaterials, 2019, 223: 119462. Cited in this article [3]

[34]	Wan X Y, Zhang H W, Pan W, Li N, Tang B. Chem. Commun., 2021, 57(44): 5402. Cited in this article [1]

[35]	Ren W X, Kong F, Shao Y Q, Huang Q Y, Sun L F, Feng J, Dong Y B. Chem. Commun., 2022, 58(34): 5245. Cited in this article [1]

[36]	Liang S, Deng X R, Ma P A, Cheng Z Y, Lin J. Adv. Mater., 2020, 32(47): 2003214. Cited in this article [1]

[37]	Liu S N, Zhou Y, Hu C L, Cai L H, Liu Z D, Pang M L. Chem. Commun., 2021, 57(66): 8178. Cited in this article [3]

[38]	Guo J, Kong S Y, Lian Y, Zhao M T. Chem. Commun., 2024, 60(8): 918. Cited in this article [1]

[39]	Liu J T, Huang J, Zhang L, Lei J P. Chem. Soc. Rev., 2021, 50(2): 1188. Cited in this article [1]

[40]	Wang D W, Zhang Z, Lin L, Liu F, Wang Y B, Guo Z P, Li Y H, Tian H Y, Chen X S. Biomaterials, 2019, 223: 119459. Cited in this article [3]

[41]	Guan Q, Zhou L L, Li Y A, Li W Y, Wang S M, Song C, Dong Y B. ACS Nano, 2019, 13(11): 13304. Cited in this article [3]

[42]	Shi Y S, Liu S N, Liu Y, Sun C Q, Chang M Y, Zhao X Y, Hu C L, Pang M L. ACS Appl. Mater. Interfaces, 2019, 11(13): 12321. Cited in this article [1]

[43]	Feng J, Ren W X, Gao J L, Li F, Kong F, Yao B J, Dong Y B. ACS Appl. Mater. Interfaces, 2021, 13(15): 17243. Cited in this article [1]

[44]	Zhao S S, Guo X P, Pan X H, Huang Y B, Cao R. Chem. Eng. J., 2023, 457: 141017. Cited in this article [1]

[45]	Dutta D, Wang J B, Li X, Zhou Q H, Ge Z S. Small, 2022, 18(37): 2202369. Cited in this article [1]

[46]	Liu Y L, Yang K, Wang J, Tian Y Z, Song B, Zhang R P. Mater. Today Bio, 2024, 25: 100981. Cited in this article [1]

[47]	Zhou J, Yu G C, Huang F H. Chem. Soc. Rev., 2017, 46(22): 7021. Cited in this article [1]

[48]	Li T, Wang D W, Guo Z P, Lin L, Meng M, Liu C, Hao K, Pang X, Tian H Y, Chen X S. Biomater. Sci., 2023, 11(19): 6524. Cited in this article [1]

[49]	He H Z, Du L H, Xue H M, Wu J, Shuai X T. Acta Biomater., 2022, 149: 297. Cited in this article [1]

[50]	Hu J, Hu J, Wu W R, Qin Y F, Fu J J, Liu C, Seeberger P H, Yin J. Acta Biomater., 2022, 148: 206. Cited in this article [1]

[51]	Li W Y, Wan J J, Kan J L, Wang B, Song T, Guan Q, Zhou L L, Li Y A, Dong Y B. Chem. Sci., 2023, 14(6): 1453. Cited in this article [3]

[52]	Chen P G, Li Y X, Dai Y Y, Wang Z M, Zhou Y P, Wang Y, Li G P. Photodiagn. Photodyn. Ther., 2024, 46: 104063. Cited in this article [1]

[53]	Zhao L Z, Yuan W, Tham H P, Chen H Z, Xing P Y, Xiang H J, Yao X, Qiu X C, Dai Y, Zhu L L, Li F Y, Zhao Y L. Small, 2017, 13(29): 1700963. Cited in this article [1]

[54]	Wang K, Zhang Z, Lin L, Hao K, Chen J, Tian H Y, Chen X S. ACS Appl. Mater. Interfaces, 2019, 11(43): 39503. Cited in this article [3]

[55]	Liu S N, Liu Z D, Meng Q, Chen C X, Pang M L. ACS Appl. Mater. Interfaces, 2021, 13(48): 56873. Cited in this article [1]

[56]	Wang X W, Zhong X Y, Liu Z, Cheng L. Nano Today, 2020, 35: 100946. Cited in this article [1]

[57]	Tang Y K, Ge L, Jiang L, Jiang X Q. Nano Today, 2024, 55: 102166. Cited in this article [1]

[58]	Pan S Z, Chen L, Song C K, Fan T, Hao B, Zhang L, Li D H, Geng Q. Genomics, 2022, 114(3): 110355. Cited in this article [1]

[59]	Lu Z X, Bai S, Jiang Y H, Wu S Y, Xu D Z, Chen Y L, Lan Y L, An Y B, Mao J S, Liu X, Liu G. Adv. Funct. Mater., 2022, 32(45): 2207749. Cited in this article [1]

[60]	Wang D W, Lin L, Li T, Meng M, Hao K, Guo Z P, Chen J, Tian H Y, Chen X S. Adv. Mater., 2022, 34(45): 2205924. Cited in this article [1]

[61]	Fan W P, Yung B C, Chen X Y. Angew. Chem., Int. Ed., 2018, 57(28): 8383. Cited in this article [1]

[62]	Fan W P, Lu N, Shen Z Y, Tang W, Shen B, Cui Z W, Shan L L, Yang Z, Wang Z T, Jacobson O, Zhou Z J, Liu Y J, Hu P, Yang W J, Song J B, Zhang Y, Zhang L W, Khashab N M, Aronova M A, Lu G M, Chen X Y. Nat. Commun., 2019, 10(1): 1241. Cited in this article [1]

[63]	Zhao P H, Jin Z K, Chen Q, Yang T, Chen D Y, Meng J, Lu X F, Gu Z, He Q J. Nat. Commun., 2018, 9(1): 4241. Cited in this article [1]

[64]	Wan X Y, Zheng T, Wang D W, Pan W, Gao Y N, Li N, Tang B. Chem. Commun., 2022, 58(84): 11803. Cited in this article [1]

[65]	Feng J, Ren W X, Kong F, Zhang C, Dong Y B. Sci. China Mater., 2022, 65(4): 1122. Cited in this article [3]

[66]	Lou H, Chu L C, Zhou W B, Dou J L, Teng X T, Tan W, Zhou B L. J. Mater. Chem. B, 2022, 10(39): 7955. Cited in this article [3]

[67]	Zhang L, Xiao Y, Yang Q C, Yang L L, Wan S C, Wang S, Zhang L, Deng H, Sun Z J. Adv. Funct. Mater., 2022, 32(29): 2201542. Cited in this article [1]

[68]	Zhang X, Wang S L, Tang K, Pan W, Xu H J, Li Y H, Gao Y N, Li N, Tang B. ACS Appl. Mater. Interfaces, 2022, 14(27): 30618. Cited in this article [1]

[69]	Wang D W, Li T, Lin L, Meng M, Hao K, Guo Z P, Chen J, Tian H Y, Chen X S. Nano Today, 2024, 54: 102088. Cited in this article [3]

[70]	Zhou S H, Wu C G, Shen P F, Zhou L M, Wang W B, Lv K, Wei C X, Li G W, Ma D, Xue W. Chem. Eng. J., 2024, 481: 148618. Cited in this article [3]