Application of Polyurethane Materials in Bone Defect Repair

Weimo Han, Yahui Wang, Yin Li, Jianan Yan, Zhiqin Li, Di Huang

Prog Chem ›› 2025, Vol. 37 ›› Issue (8) : 1188-1203.

PDF(15449 KB)
image
Home Journals Progress in Chemistry
Progress in Chemistry

Abbreviation (ISO4): Prog Chem      Editor in chief: Jincai ZHAO

About  /  Aim & scope  /  Editorial board  /  Indexed  /  Contact  / 
Online first  /  Current issue  /  All issues  /  Top access  /  RSS
PDF(15449 KB)
Prog Chem ›› 2025, Vol. 37 ›› Issue (8) : 1188-1203. DOI: 10.7536/PC241103
Review

Application of Polyurethane Materials in Bone Defect Repair

Author information +
History +

Abstract

Bone defects caused by accidents or diseases are a common and serious problem in orthopedic surgery. Finding ideal bone repair materials has become a hotspot in current bone tissue engineering. Polyurethane （PU） is a multiblock copolymer with a microphase-separated structure formed by alternating soft and hard segments. Its application properties - such as mechanical performance，biocompatibility，and biodegradability-can be tailored by adjusting the soft segment structure，hard segment ratio，crystallinity，and other factors，demonstrating broad prospects in the field of bone defect repair. This paper reviews recent research on the design，synthesis，modification，and biological performance of PU in bone tissue engineering，with a focus on its application progress in bone regeneration，including implantable scaffolds，injectable materials，and drug carriers. The aim is to provide more insights for the future design and clinical application of PU materials.

Contents

1 Introduction

2 Development of polyurethane

3 Synthesis of polyurethane

3.1 Main raw material

3.2 Main reaction pathways

4 Structure of polyurethane

5 Properties of polyurethane

5.1 Mechanical properties

5.2 Biological activity

5.3 Biodegradation

5.4 Shape memory properties

6 Applications of polyurethane in bone defects repairing

6.1 Implanted scaffold

6.2 Injected polyurethane

6.3 Drug carrier

7 Conclusion and outlook

Key words

polyurethane / bone repair / bone tissue engineering / functionalization / osteogenesis

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations
Weimo Han , Yahui Wang , Yin Li , et al . Application of Polyurethane Materials in Bone Defect Repair[J]. Progress in Chemistry. 2025, 37(8): 1188-1203 https://doi.org/10.7536/PC241103

References

List( Publishing order | Descend order by publishing year | Descend order by cited within ) Chart analysis
[1]
Zhou J, Zhang Z Y, Joseph J, Zhang X C, Ferdows B E, Patel D N, Chen W, Banfi G, Molinaro R, Cosco D, Kong N, Joshi N, Farokhzad O C, Corbo C, Tao W. Exploration, 2021, 1(2): 20210011.
Cited in this article [1]
[2]
Shen N N, Zhang Z H, Wu F T, Zhu Z Z, Liu J R, Qi X Y, Li Q, Wang X X, Ma Q M, Xiang H F. Adv. Compos. Hybrid. Ma., 2025, 8: 38.
Cited in this article [1]
[3]
Fu Z Y, Cui J J, Zhao B, Shen S G, Lin K L. J. Orthop. Transl., 2021, 28: 118.
Cited in this article [1]
[4]
Lv Z, Ji Y, Wen G L, Liang X Y, Zhang K, Zhang W. Burns Trauma, 2024, 12: tkae036.
Cited in this article [1]
[5]
Collins M N, Ren G, Young K, Pina S, Reis R L, Oliveira J M. Adv. Funct. Mater., 2021, 31(21): 2010609.
Cited in this article [1]
[6]
Koons G L, Diba M N, Mikos A G. Nat. Rev. Mater., 2020, 5(8): 584.
Cited in this article [2]
[7]
Hebda E, Pielichowski K. Biomimetics, 2025, 10(3): 184.
Cited in this article [1]
[8]
Imani S M, Rabiee S M, Goudarzi A M, Dardel M, Tayebi L. Mater. Today Commun., 2022, 31: 103293.
Cited in this article [1]
[9]
Ravoor J, Thangavel M, Elsen S R. ACS Appl. Bio Mater., 2021, 4(12): 8129.
Cited in this article [1]
[10]
Xu C, Liu Z Z, Chen X, Gao Y, Wang W J, Zhuang X J, Zhang H, Dong X F. Chin. Chemical Lett., 2024, 35(2): 109197.
Cited in this article [1]
[11]
Aro H T, Välimäki V V, Strandberg N, Lankinen P, Löyttyniemi E, Saunavaara V, Seppänen M. Acta Orthop., 2022, 93: 519.
Cited in this article [1]
[12]
Ferreira S A, Young G, Jones J R, Rankin S. Mater. Sci. Eng. C, 2021, 118: 111393.
Cited in this article [1]
[13]
Aykora D, Uzun M. Polym. Bull., 2024, 81(10): 8595.
Cited in this article [1]
[14]
Gunatillake P A, Dandeniyage L S, Adhikari R, Bown M, Shanks R, Adhikari B. Polym. Rev., 2019, 59(3): 391.
Cited in this article [2]
[15]
Wendels S, Avérous L. Bioact. Mater., 2021, 6(4): 1083.
Cited in this article [4]
[16]
Azarmgin S, Asnarka, Torabinejad B, Asnarka, Kalantarzadeh R, Garcia H, Velazquez C A, Lopez G, Vazquez M, Rosales G, Heidari B S, Davachi S M. ACS Biomater. Sci. Eng., 2024, 10(11): 6828.
Cited in this article [3]
[17]
Wang H R, Li T, Li J, Zhao R H, Ding A, Xu F J. Prog. Polym. Sci., 2024, 151: 101803.
Cited in this article [1]
[18]
Qiu J H, Zhao H, Luan S F, Wang L, Shi H C. Biomater. Sci., 2025, 13(10): 2526.
Cited in this article [1]
[19]
Marzec M, Kucińska-Lipka J, Kalaszczyńska I, Janik H. Mater. Sci. Eng. C, 2017, 80: 736.
Cited in this article [4]
[20]
Król P, Król B. J. Mater. Sci., 2020, 55: 73.
Cited in this article [3]
[21]
Ma Y F, Hu Y, Fang Y, Li Q G, Huang Q, Shang Q Q, Zhang M, Li S H, Jia P Y, Zhou Y H. Green Mater., 2024, 1.
Cited in this article [1]
[22]
Lam K Y, Lee C S, Pichika M R, Cheng S F, Tan R Y H. J. Appl. Polym. Sci., 2024, 141(30): e55703.
Cited in this article [1]
[23]
Oliviero M, Stanzione M, D’Auria M, Sorrentino L, Iannace S, Verdolotti L. Polymers, 2019, 11(3): 480.
Cited in this article [1]
[24]
Wu D D, Tan Y, Cao Z W, Han L J, Zhang H L, Dong L S. Carbohydr. Polym., 2018, 194: 236.
Cited in this article [1]
[25]
Kordbacheh H, Katbab A A, Aghvami-Panah M, Haghighipour N. Int. J. Biol. Macromol., 2025, 288: 138681.
Cited in this article [1]
[26]
Li B, Ma Y C, Fatima K, Zhou X J, Gu X, Chen S, He C L. J. Nanobiotechnol., 2025, 23: 244.
Cited in this article [2]
[27]
Sanati A, Kefayat A, Rafienia M, Raeissi K, Siavash Moakhar R, Salamat M R, Sheibani S, Presley J F, Vali H. Mater. Des., 2022, 221: 110955.
Cited in this article [1]
[28]
Yang J Y, Liu K, Wang Z J, Rao L, Fu L L, Tang D X, Yang X J, Li Y S, Chen H Q, Liu Y. Polym. Compos., 2024, 45(6): 4961.
Cited in this article [1]
[29]
Egorikhina M N, Bokov A E, Charykova I N, Rubtsova Y P, Linkova D D, Kobyakova I I, Farafontova E A, Kalinina S Y, Kolmogorov Y N, Aleynik D Y. Polymers, 2023, 15(4): 831.
Cited in this article [1]
[30]
Luo K, Wang L, Chen X H, Zeng X Y, Zhou S Y, Zhang P C, Li J F. J. Bionic Eng., 2022, 19(1): 167.
Cited in this article [2]
[31]
Du J J, Zuo Y, Lin L L, Huang D, Niu L L, Wei Y, Wang K Q, Lin Q X, Zou Q, Li Y B. J. Mech. Behav. Biomed. Mater., 2018, 88: 150.
Cited in this article [1]
[32]
Du J J, Gan S C, Bian Q H, Fu D H, Wei Y, Wang K Q, Lin Q X, Chen W Y, Huang D. J. Biomater. Appl., 2018, 33(3): 402.
Cited in this article [1]
[33]
Vieira de Sousa T W, da Silva Reis F, Gomes de Melo W G, Rai A M, Rai M, Lobo A O, Martins Argôlo Neto N, de Matos J M E. ACS Omega, 2025, 10(6): 5478.
Cited in this article [1]
[34]
Król P. Prog. Mater. Sci., 2007, 52(6): 915.
Cited in this article [2]
[35]
Szczepańczyk P, Szlachta M, Złocista-Szewczyk N, Chłopek J, Pielichowska K. Polymers, 2021, 13(6): 946.
Cited in this article [2]
[36]
Zhou J, Cao H Q, Chang R X, Shan G R, Bao Y Z, Pan P J. ACS Macro Lett., 2018, 7(2): 233.
Cited in this article [1]
[37]
Shan J W, Zhu Y B, Ni L L, Pan P J. Chin. J. Polym. Sci., 2024, 42(12): 1976.
Cited in this article [1]
[38]
Fernández-d’Arlas B, Ramos J A, Saralegi A, Corcuera M, Mondragon I, Eceiza A. Macromolecules, 2012, 45(8): 3436.
Cited in this article [7]
[39]
Pourmohammadi-Mahunaki M, Haddadi-Asl V, Roghani-Mamaqani H, Koosha M, Yazdi M. Polym. Bull., 2022, 79(10): 8653.
Cited in this article [5]
[40]
Li L M, Zuo Y, Zou Q, Yang B Y, Lin L L, Li J D, Li Y B. ACS Appl. Mater. Interfaces, 2015, 7(40): 22618.
Cited in this article [5]
[41]
Zhang Y C, Hu J L, Zhu S S, Qin T W, Ji F L. Compos. Sci. Technol., 2019, 180: 14.
Cited in this article [5]
[42]
Deng L F, Yan Y F. Chinese Journal of Reparative and Reconstructive Surgery, 2018, 7: 815.
Cited in this article [2]
[43]
Zhang T Y, Li J X, Wang Y H, Han W M, Wei Y, Hu Y C, Liang Z W, Lian X J, Huang D. Tissue Eng. Part B Rev., 2024, 30(1): 60.
Cited in this article [1]
[44]
Chen X H, Huang Z X, Yang Q, Zeng X Y, Bai R Q, Wang L. Biomed. Mater., 2023, 18: 059501.
Cited in this article [3]
[45]
Alhamoudi F H. J. Mater. Res., 2024, 39(6): 1011.
Cited in this article [1]
[46]
Chen C M, Chen S M, Lin S F, Liang H C, Wu C C. Polymers, 2021, 13(15): 2552.
Cited in this article [1]
[47]
Zhao J, Lu X, Duan K, Guo L Y, Zhou S B, Weng J. Colloids Surf. B Biointerfaces, 2009, 74(1): 159.
Cited in this article [1]
[48]
Li L M, Li Q, Gui L, Deng Y, Wang L, Jiao J L, Hu Y R, Lan X Q, Hou J H, Li Y, Lu D. Bioact. Mater., 2023, 19: 24.
Cited in this article [11]
[49]
Tang J J, Zhang Y L, Fang W, Man Y, Zhang J Z, Zhao Q, Lei X Y, Chen J Q, Li J D, Li Y B, Zuo Y. Chem. Eng. J., 2023, 460: 141630.
Cited in this article [7]
[50]
Ghimire U, Jang S R, Adhikari J R, Kandel R, Song J H, Park C H. Int. J. Biol. Macromol., 2024, 264: 130602.
Cited in this article [1]
[51]
Jia B, Huang H Y, Dong Z C, Ren X Y, Lu Y Y, Wang W Z, Zhou S W, Zhao X, Guo B L. Chem. Soc. Rev., 2024, 53(8): 4086.
Cited in this article [1]
[52]
Naureen B, Haseeb A S M A, Basirun W J, Muhamad F. Mater. Sci. Eng. C, 2021, 118: 111228.
Cited in this article [1]
[53]
Yuvarani I, Senthilkumar S, Venkatesan J, Kim S K, Al-Kheraif A A, Anil S, Sudha P N. J. Biomater. Tissue Eng., 2015, 5(8): 665.
Cited in this article [1]
[54]
Li Y, Thouas G A, Chen Q-Z. RSC Adv., 2012, 2(22): 8229.
Cited in this article [1]
[55]
Song N J, Jiang X, Li J H, Pang Y, Li J S, Tan H, Fu Q. Chin. J. Polym. Sci., 2013, 31(10): 1451.
Cited in this article [1]
[56]
Khattab M, Abdel Hady N, Dahman Y. J. Funct. Biomater., 2023, 14(3): 118.
Cited in this article [1]
[57]
Nilawar S, Chatterjee K. Ind. Crops Prod., 2022, 185: 115136.
Cited in this article [1]
[58]
Shaabani A, Sedghi R, Motasadizadeh H, Dinarvand R. Chem. Eng. J., 2021, 411: 128449.
Cited in this article [2]
[59]
Lei X Y, Yang B Y, Chen J, Yang F, Tang J J, Li J H, Zhao Q, Zhang J Z, Li J D, Li Y B, Zuo Y. ACS Appl. Mater. Interfaces, 2024, 16(1): 111.
Cited in this article [1]
[60]
Sougrati L, Wendels S, Dinescu S, Balahura L R, Sleiman L, Avérous L. Sustain. Mater. Technol., 2023, 37: e00656.
Cited in this article [2]
[61]
Wang Y L, Ruan C S, Sun J X, Zhang M L, Wu Y L, Peng K. Polym. Degrad. Stab., 2011, 96(9): 1687.
Cited in this article [1]
[62]
Ruan C S, Hu N, Hu Y, Jiang L X, Cai Q Q, Wang H Y, Pan H B, Lu W W, Wang Y L. Polymer, 2014, 55(4): 1020.
Cited in this article [1]
[63]
Ruan C S, Hu Y, Jiang L X, Cai Q Q, Pan H B, Wang H Y. J. Appl. Polym. Sci., 2014, 131(19): 40527.
Cited in this article [1]
[64]
Ma Y F, Hu N, Liu J, Zhai X Y, Wu M M, Hu C S, Li L, Lai Y X, Pan H B, Lu W W, Zhang X Z, Luo Y F, Ruan C S. ACS Appl. Mater. Interfaces, 2019, 11(9): 9415.
Cited in this article [1]
[65]
Cetina-Diaz S M, Chan-Chan L H, Vargas-Coronado R F, Cervantes-Uc J M, Quintana-Owen P, Paakinaho K, Kellomaki M, Di Silvio L, Deb S, Cauich-Rodríguez J V. J. Mater. Chem. B, 2014, 2(14): 1966.
Cited in this article [1]
[66]
Mendonça L H P, Lopes É S N, Rodrigues I C P, de Oliveira M F, Gabriel L P. J. Mater. Res. Technol., 2022, 20: 3697.
Cited in this article [1]
[67]
Amiryaghoubi N, Noroozi Pesyan N, Fathi M, Omidi Y. Colloids Surf. A Physicochem. Eng. Aspects, 2022, 634: 127895.
Cited in this article [2]
[68]
Bagheri F, Saudi A, Bidram E, Asefnejad A, Sanati A, Zarrabi A, Rafienia M. Phys. Scr., 2024, 99(4): 045023.
Cited in this article [1]
[69]
Xia Y L, He Y, Zhang F H, Liu Y J, Leng J S. Adv. Mater., 2021, 33(6): 2000713.
Cited in this article [1]
[70]
Zheng Y F, Du Y D, Chen L, Mao W, Pu Y, Wang S, Wang D. Biomater. Sci., 2024, 12(8): 2033.
Cited in this article [1]
[71]
Pfau M R, Grunlan M A. J. Mater. Chem. B, 2021, 9(21): 4287.
Cited in this article [1]
[72]
Li T T, Chen L, Yuan Y, Shi R F. Polymers, 2023, 15(3): 556.
Cited in this article [1]
[73]
Ha Y-M, Seo H C, Kim Y O, Khil M S, Cho J W, Lee J S, Jung Y C. Macromol. Res., 2020, 28(3): 234.
Cited in this article [1]
[74]
Mondal S, Hu J L. Polym. Plast. Technol. Eng., 2007, 46(10): 939.
Cited in this article [1]
[75]
Eyvazzadeh Kalajahi A, Rezaei M, Abbasi F, Mir Mohamad Sadeghi G. Polym. Plast. Technol. Eng., 2017, 56(18): 1977.
Cited in this article [1]
[76]
Mondal S. Polym. - Plast. Technol. Mater., 2021, 60: 1491.
Cited in this article [2]
[77]
Bhanushali H, Amrutkar S, Mestry S, Mhaske S T. Polym. Bull., 2022, 79(6): 3437.
Cited in this article [1]
[78]
Zhang Y C, Hu J L, Xie R Q, Yang Y H, Cao J, Tu Y H, Zhang Y, Qin T W, Zhao X. Acta Biomater., 2020, 103: 293.
Cited in this article [4]
[79]
Yu J H, Xia H, Teramoto A, Ni Q Q. J. Biomed. Mater. Res. Part A, 2018, 106(1): 244.
Cited in this article [1]
[80]
Yuan L, Xiao L, Zhang J, Xiao Y, Yu L X, Yang K K, Wang Y Z. Biomacromolecules, 2024, 25(6): 3795.
Cited in this article [3]
[81]
Xu X W, Skelly J D, Song J. ACS Appl. Mater. Interfaces, 2023, 15(2): 2693.
Cited in this article [3]
[82]
Ghorai S K, Maji S, Subramanian B, Maiti T K, Chattopadhyay S. Carbon, 2019, 141: 370.
Cited in this article [1]
[83]
Takaoka Y, Fujibayashi S, Onoe H, Goto K, Otsuki B, Kawai T, Okuzu Y, Shimizu T, Ikeda N, Orita K, Honda S, Ikezaki T, Yabutsuka T, Matsuda S. Acta Biomater., 2024, 177: 243.
Cited in this article [1]
[84]
Chen C F, Chou Y S, Lee T M, Fu Y C, Ou S F, Chen S H, Lee T C, Wang Y H. Int. J. Mol. Sci., 2024, 25(12): 6440.
Cited in this article [1]
[85]
Ghorai S K, Roy T, Maji S, Guha Ray P, Sarkar K, Dutta A, De A, Bandyopadhyay S, Dhara S, Chattopadhyay S. Chem. Eng. J., 2022, 429: 132179.
Cited in this article [1]
[86]
Shrestha S, Shrestha B K, Ko S W, Kandel R, Park C H, Kim C S. Carbohydr. Polym., 2021, 251: 117035.
Cited in this article [1]
[87]
Zhao Q, Chen J Q, Tang J J, Lei X Y, Zhang J Z, Zhang Y L, Li J D, Zuo Y, Li Y B. Adv. Funct. Mater., 2024, 34(25): 2316428.
Cited in this article [1]
[88]
Wang C, Huang W, Zhou Y, He L B, He Z, Chen Z L, He X, Tian S, Liao J M, Lu B H, Wei Y, Wang M. Bioact. Mater., 2020, 5(1): 82.
Cited in this article [1]
[89]
Haleem A, Javaid M, Khan R H, Suman R. J. Clin. Orthop. Trauma, 2020, 11: S118.
Cited in this article [1]
[90]
Zhang Y C, Li C R, Zhang W, Deng J J, Nie Y Y, Du X F, Qin L, Lai Y X. Bioact. Mater., 2022, 16: 218.
Cited in this article [7]
[91]
Liu X C, Tang B, Li Q, Xiao W, Wang X L, Xiao H J, Zheng Z. Colloids Surf. B Biointerfaces, 2022, 219: 112835.
Cited in this article [7]
[92]
Li Q, Tang X C, Chen B Y, Wang X L, Xiao H J, Zheng Z. Adv. Healthcare Mater., 2024, 13: 2301870.
Cited in this article [7]
[93]
Tao M H, Fang Z, Zhu Y T, Ju Y, Hou Z G, Fu M M, Lu Z H, Cai D Z, Yang J, Guo J S. Bioact. Mater., 2024, 41: 108.
Cited in this article [5]
[94]
Hou Y, Jiang N, Zhang L, Li Y B, Meng Y Z, Han D M, Chen C, Yang Y, Zhu S S. ACS Appl. Mater. Interfaces, 2017, 9(31): 25808.
Cited in this article [1]
[95]
Zhang J Z, Lei X Y, Tang J J, Chen J, Zhao Q, Fang W, Zhang Y L, Li Y B, Zuo Y. J. Bionic Eng., 2022, 19(2): 483.
Cited in this article [1]
[96]
Rezaei H, Shahrezaee M, Jalali Monfared M, Fathi Karkan S, Ghafelehbashi R. J. Polym. Eng., 2021, 41(5): 375.
Cited in this article [1]
[97]
Jaiswal R, Wadetwar R. Mater. Today Commun., 2025, 42: 111249.
Cited in this article [1]
[98]
Feng P, Yang F, Jia J Y, Zhang J, Tan W, Shuai C J.Int. J. Extrem. Manuf., 2024, 6(6): 062011.
Cited in this article [1]
[99]
Gharehdaghi N, Nokhbatolfoghahaei H, Khojasteh A. Biomed. Mater., 2025, 20(1): 012003.
Cited in this article [1]
[100]
Wang Z, Ma D, Liu J, Xu S, Qiu F, Hu L Q, Liu Y M, Ke C N, Ruan C S. Bioact. Mater., 2025, 48: 370.
Cited in this article [1]

The contributions made by students Hu Qingbiao, Xi Jiawei, and Li Ruifang during the literature review.

Funding

the National Natural Science Foundation of China(12272253)
the Natural Science Foundation of Shanxi Province，China(202203021212270)
PDF(15449 KB)

Accesses

Citation

Detail
Sections
Recommended

/

〈 〉