Progress in Chemistry

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Segment Solubilizing Strategy in Protein Chemical Synthesis

Deng Xiangyu, Zhang Baochang, Qu Qian

Prog Chem, 2023, 35(11): 1579-1594. DOI: 10.7536/PC230325

Fig.1 Reasons for poor solubility of peptide fragments^[56]

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Fig.2 Methods for improving the solubility of peptides^{[57⇓⇓⇓⇓⇓~63]}
Scheme 1 C terminal thioester solubilizing tag^[67]
Fig.3 Division of DGK hydrophilic peptides^[67]
Fig.4 Other C-terminal solubilizing tags^[70⇓~72]
Fig.5 N-terminal solubilizing tags^[73,74]
Scheme 2 Base-liable N-terminal solubilizing tags^[73]
Fig.6 Side chain-based solubilizing tags
Scheme 3 Cys side chain solubilizing strategy developed by Brik et al^[78]
Scheme 4 Total chemical synthesis of histone H4^[78]
Scheme 5 Cys side chain solubilizing strategy developed by Yoshiya et al^[81]
Scheme 6 Total chemical synthesis of CP149^[81]ALC
Scheme 7 Cys side chain solubilizing strategy developed by Deber et al^[84]
Scheme 8 Cys side chain solubilizing strategy developed by Li et al^[85]
Scheme 9 Total chemical synthesis of membrane protein FCER1G^[85]
Scheme 10 Lys side chain solubilizing strategy developed by Danishefsky et al^[89]
Scheme 11 Optimization of physical and chemical properties of hEPO peptide fragment^[89]
Scheme 12 Lys side chain solubilizing strategy developed by Hojo et al^[91]
Scheme 13 Total chemical synthesis of IL-2^[91]
Scheme 14 Lys side chain solubilizing strategy developed by Kay et al^[94]
Scheme 15 Total chemical synthesis of GroES^[94]
Fig.7 The structure of Ddap^[96]
Scheme 16 Lys side chain solubilizing strategy developed by Yoshiya et al^[97]
Scheme 17 Strategy developed by Imperial et al^[99]
Scheme 18 Gln side chain solubilizing strategy developed by Liu et al^[100]
Scheme 19 Total chemical synthesis of LC3-Ⅱ^[100]
Fig.8 Irreversible backbone modification^[102]
Fig.9 Hmb and its derivatives^[104,105]
Scheme 20 The RBM strategy^[56,106]
Scheme 21 Total chemical synthesis of p7 ion channel^[106]

模态框（Modal）标题

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