Aimed at the complicated situations faced by oil-gas exploration, such as small size of traps and fast geological sedimentary phase transitions.It is urgent to research by insufficient seismic resolution, time-frequency analysis technology can be used to focus fine seismic signals in the time and frequency domains, in order to improve the accuracy of identifying small oil-gas targets. On the basis of explaining the principle of time-frequency analysis technology and organically combining it with sequence stratigraphy analysis, this article establishes the directionality and response intensity of the energy cluster of favorable sand bodies in the lake bottom fan with frequency changes, and reveals the differences in time-frequency characteristics caused by changes in lithology, physical properties, or pore fluid properties of the sand bodies in the lake bottom fan. The research results show that based on the frequency response distribution characteristics of the lake bottom fan, using time-frequency analysis technology to analogize the instantaneous frequency change characteristics of sweet spots in each lobe of the A lake bottom fan in Weizhou that can reflect the dominant frequency change pattern of favorable sand bodies in the lake bottom fan, and can qualitatively predict the lithological combination information of sweet spots in each lobe reservoir of the lake bottom fan. In addition, it can reduced the ambiguity of lithological interpretation of sweet spots in the lobe, which provided technical supports for the discovery of favorable sandstones and oil-gas development.