Ordos Basin is one of the important uranium energy bases in China. In recent years, the exploration research shows that there are abundant sandstone type uranium deposits in Luohe Formation in Pengyang area, southwest of the basin. Some scholars found that the metallogenic causes of sandstone-type uranium deposits are related to deep oil and gas through geochemical research methods. However, there are relatively few geophysical studies. On the basis of previous studies, this paper describes the fault distribution in the study area through structural analysis of seismic data. By using seismic research methods such as logging, seismic attribute analysis and reservoir wave impedance inversion, the geophysical response characteristics, mainly reflected in high gamma, strong amplitude, low frequency, low mid-high wave impedance and low velocity (compared to similar uranium-free formations), etc. Of oil and gas reservoirs and uranium-bearing sandstones are identified, so as to divide uranium-bearing sandstones and favorable oil and gas areas, and discuss the relationship between uranium mineralization and deep oil and gas from the perspective of geophysics. The final study shows that the deep oil and gas in Pengyang area of Ordos Basin will migrate along the fault to the shallow layer, and REDOX reaction will occur with the uranium-bearing fluid, and then reduce and mineralization in the shallow sandstone layer.