Abnormal pressure is closely related to the generation, migration and accumulation of oil and gas and the preservation of oil and gas reservoirs, so accurate prediction of formation pressure is essential in oil and gas exploration.The prediction of formation pressure, which is generally developed with high pressure in Xihu sag, cannot meet the exploration demand in this area. In this paper, the relationship between shear wave velocity and formation pressure is established based on petrophysical model, and further applied to pre-stack simultaneous inversion seismic data for pressure prediction, so as to improve the multi-solutionof formation pressure prediction and improve the prediction accuracy. Based on Hertz-Mindlin model considering pressure and Gassmann fluid replacement equation, the relationship between shear wave velocity and effective stress is established by combining mineral composition pore fluid to simulate elastic characteristics of underground rock strata. Combined with effective stress theorem, formation pressure is predicted on the basis of petrophysical model, the single well formation pressure prediction of Pinghu Formation in Pinghu structural belt on the west slope of Xihu sag is compared with the conventional Eaton method. The proposed method is more accurate Then the relationship between effective stress and the product of shear wave velocity and shear wave impedance is applied to seismic data to predict seismic formation pressure. According to the well profile of predicted formation pressure, the well bypass is relatively matched with the well formation pressure, and the predicted formation pressure coefficient is consistent with the measured results, which accords with the pressure coefficient distribution law of the west slope of Xihu sag. In this paper, the seismic formation pressure prediction based on petrophysical theory is realized by combining logging petrophysical seismology.