The strong-energy multiple wave interference developed within the Ordovician strata in the desert area of Tarim Basin has become a key factor restricting high-precision imaging of fault-controlled fracture-cavity reservoirs. This paper conducts systematic research on multiple wave issues in seismic exploration of Tarim Basin. Aiming at the composite interference problem of long-period surface multiples and short-period interbed multiples unique to desert areas, we propose a combined multiple suppression technology system suiTable for ultra-deep fault-karst reservoir exploration creatively. The cascaded processing workflow integrating 3D Generalized Surface Multiple Prediction (3D-GSMP) and adaptive plane wavefield continuation method breaks through the limitations of traditional single suppression methods. Application examples demonstrate that this combined approach achieves effective multiple suppression while preserving valid signals, improves imaging accuracy of fault-controlled fracture-cavity reservoir targets, and provides new solutions for multiple wave issues in ultra-deep carbonate oil and gas exploration in desert areas.