The tight oil resources in the Triassic Yanchang Formation in the Ganquan area of the southern Ordos Basin have great potential. However, the research on rock mechanical parameters and in-situ stress analysis of its tight sandstone reservoirs is relatively lagging. In this paper, small cores with angles of 0° (parallel, H), 45° (oblique intersection) and 90° (perpendicular, V) to the bedding plane were drilled, and X-ray diffraction, scanning electron microscopy and triaxial stress experiments were carried out. The research shows that the minerals in the Chang 8 layer samples are mainly quartz (31.8%), plagioclase (22.6%) and clay (26.6%), with a total content of 81.0%. Scanning electron microscopy shows that there are quartz overgrowth, intergranular and grain-surface clay mineral filling in the core, and there are intergranular residual pores. Under different bedding directions, the Kaiser point stress value, peak load value and compressive strength decrease in turn, while the elastic modulus and Poisson's ratio first decrease and then increase. There is a logarithmic function relationship between the pore volume compressibility coefficient and the effective stress. Through the analysis and prediction of logging data and experimental data, the dynamic elastic modulus is higher than the static one, and the dynamic Poisson's ratio is lower than the static one. The prediction results of compressive strength, tensile strength and in-situ stress are consistent with the experimental results. The research results provide new indicators for the prediction of "sweet spots" in the integration of geology and engineering of tight oil reservoirs in the Chang 8 interval of the Ganquan area. They have important guiding value for the identification of comprehensive sweet spots in tight oil reservoirs in the southern part of the Ordos Basin, the optimization of horizontal well trajectories, the design of fracturing stages and clusters, and the optimization of construction parameters.