In the process of in-situ leaching sandstone Uranium deposit exploration, Uranium reservoir heterogeneity can indicate the change law of Uranium ore layer lithology, physical properties and connectivity in the vertical and horizontal directions, which is an important content of studying Uranium mineralization process and spatial positioning prediction. At present, scholars have conducted preliminary research on Uranium reservoir heterogeneity, but there is no unified understanding on heterogeneity classification and quantitative evaluation methods. Different Uranium reservoir heterogeneity classifications have different evaluation methods. Based on previous research, this paper summarizes the classification and evaluation methods of Uranium reservoir heterogeneity, introduces the imbalance measurement theory for the first time to quantitatively characterize Uranium reservoir heterogeneity, and uses the interlayer coefficient and logging data theoretical model as imbalance measurement characterization parameters, which can achieve the purpose of quantitatively characterizing Uranium reservoir heterogeneity. This method was applied to the Shawan Formation Uranium reservoir in the Chepaizi area. The heterogeneity of the Shawan Formation was evaluated from three aspects: plane, interlayer and intralayer. The standard for dividing the degree of heterogeneity of sand bodies was clarified in combination with the imbalance measurement index, and the degree of heterogeneity was divided into five categories: weak, relatively weak, medium, relatively strong and strong. It is believed that the good plane continuity of the sand bodies in the lower and upper sections of the Shawan Formation can provide a good ore-bearing space for Uranium mineralization. The medium interlayer heterogeneity and the weak and medium intralayer heterogeneity are favorable places for Uranium mineralization. The process of heterogeneity from weak to strong is accompanied by the increase of reducing substances, and the oxidized ore-bearing fluid gradually "unloads" and deposits to form Uranium ore bodies.